| SETD8在肿瘤发生发展和免疫调节中作用及机制的研究进展 |
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| 引用本文： | 陈萱1,' target='_blank'>2,袁露3,臧龙正4,玄延花1,' target='_blank'>5,朴丽花1,' target='_blank'>2. SETD8在肿瘤发生发展和免疫调节中作用及机制的研究进展[J]. 现代肿瘤医学, 2022, 0(19): 3602-3606. DOI: 10.3969/j.issn.1672-4992.2022.19.032 |
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| 作者姓名： | 陈萱1 ' target='_blank'>2 袁露3 臧龙正4 玄延花1 ' target='_blank'>5 朴丽花1 ' target='_blank'>2 |
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| 作者单位： | 1.延边大学医学院再生医学研究所;2.组织学与胚胎学教研室;4.预防医学教研室;5.病理学教研室,吉林 延吉 133002;3.安徽师范大学安徽省生物资源保护与开发重点实验室,安徽 芜湖 241000 |
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| 基金项目： | National Natural Science Foundation of China（No.81760531）;国家自然科学基金资助项目（编号:81760531）;吉林省卫生健康科技能力提升项目（编号:2021JC062）;吉林省教育厅“十三五”科学技术项目（编号:JJKH20191138KJ） |
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| 摘 要： | SETD8/SET8/Pr-SET7/KMT5A是唯一已知的催化组蛋白H4K20甲基化的赖氨酸单甲基转移酶（H4K20me1）,参与组蛋白翻译后修饰,染色质和细胞核功能的调节,对多种细胞生命活动产生了重要影响。临床上越来越多的证据表明,SETD8与癌症分期和不良预后密切相关,并参与免疫调节。因此,明确SETD8在肿瘤与免疫调节中的作用,将为肿瘤治疗提供更多理论依据。现对SETD8在肿瘤发生发展和免疫调节中的作用机制予以综述。
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| 关 键 词： | SETD8 甲基转移酶 肿瘤 免疫 |
Research progress on the role and mechanism of SETD8 in tumor development and immune regulation |
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| CHEN Xuan,' target='_blank'>,YUAN Lu,ZANG Longzheng,XUAN Yanhua,' target='_blank'>,PIAO Lihua,' target='_blank'>. Research progress on the role and mechanism of SETD8 in tumor development and immune regulation[J]. Journal of Modern Oncology, 2022, 0(19): 3602-3606. DOI: 10.3969/j.issn.1672-4992.2022.19.032 |
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| Authors: | CHEN Xuan ' target='_blank'> YUAN Lu ZANG Longzheng XUAN Yanhua ' target='_blank'> PIAO Lihua ' target='_blank'> |
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| Affiliation: | 1.Institute of Regenerative Medicine;2.Department of Histology and Embryology;4.Department of Preventive Medicine;5.Department of Pathology,Yanbian University School of Medicine,Jilin Yanji 133002,China;3.Anhui Provincial Key Laboratory of Biological Resource Conservation and Development,Anhui Normal University,Anhui Wuhu 241000,China. |
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| Abstract: | SETD8/SET8/Pr-SET7/KMT5A is the only known lysine mono methyltransferase(H4K20me1) of catalytic histone H4K20 methylation,which is involved in post-translational modification of histones,regulation of chromatin and nucleus functions,and has important influences on a variety of cellular life activities.Accumulating clinical evidence suggests that SETD8 is closely related to cancer staging and poor prognosis,and it is involved in immune regulation.Therefore,clarifying the role of SETD8 in tumor and immune regulation will provide more theoretical basis for tumor therapy.The mechanism of SETD8 in tumor development and immune regulation is reviewed here. |
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| Keywords: | SETD8 methyltransferase tumor immune regulation |
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