| 肠道微生物在结直肠癌发生发展及诊疗中作用的新进展 |
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| 引用本文： | 王朗玥,赵琦,吴华星. 肠道微生物在结直肠癌发生发展及诊疗中作用的新进展[J]. 现代肿瘤医学, 2022, 0(11): 2082-2085. DOI: 10.3969/j.issn.1672-4992.2022.11.035 |
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| 作者姓名： | 王朗玥 赵琦 吴华星 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院腔镜科,黑龙江 哈尔滨 150000 |
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| 基金项目： | 海燕科研基金计划(编号:JJZD2020-16) |
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| 摘 要： | 肠道生态系统的改变会影响人类的健康,甚至引发结直肠癌。大量证据表明,在结直肠癌患者的肠道中普遍存在一种病理性微生物群失衡状态。本综述从免疫与炎症反应、肠道微生物代谢产物和基因损伤三个方面总结了肠道微生物引发结直肠癌的机制,介绍了肠道微生物群相关的结直肠癌诊断标志物,分析了肠道微生物在结直肠癌放化疗及免疫治疗中的新进展,希望为结直肠癌的防治及诊疗提供新的机会。
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| 关 键 词： | 肠道微生物 结直肠癌 肿瘤标志物 代谢产物 |
New progress of gut microbes in the development and clinical application of colorectal cancer |
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| WANG Langyue,ZHAO Qi,WU Huaxing. New progress of gut microbes in the development and clinical application of colorectal cancer[J]. Journal of Modern Oncology, 2022, 0(11): 2082-2085. DOI: 10.3969/j.issn.1672-4992.2022.11.035 |
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| Authors: | WANG Langyue ZHAO Qi WU Huaxing |
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| Affiliation: | Endoscopy Room,Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150000,China. |
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| Abstract: | Changes in the intestinal ecosystem will affect human health and even cause colorectal cancer.A large amount of evidence shows that a pathological imbalance of the microbiota is common in the intestines of patients with colorectal cancer.This review summarizes the mechanism of colorectal cancer caused by intestinal microbes from three aspects:immune and inflammatory response,intestinal microbial metabolites,and gene damage,introduces the diagnostic markers of colorectal cancer related to the intestinal microbiota,and analyzes new progress of gut microbes in colorectal cancer radiotherapy,chemotherapy and immunotherapy.Hope to provide new opportunities for the prevention and treatment of colorectal cancer. |
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| Keywords: | gut microbes colorectal cancer tumor markers metabolites |
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