基于“阳化气，阴成形”及伏阳学说的肿瘤病机刍议

中医对肿瘤病机的研究一直是中医基础研究的热点，该研究基于“阳化气，阴成形”及伏阳学说，结合了现代医学研究成果，系统阐述了肿瘤发病的病机。认为肿瘤的发生发展可能与内外因作用下形成的阳虚阴盛体质有关。该体质状态下机体容易产生与现代医学中的增生、结节、息肉等概念类似的痰、湿、瘀、毒等病理产物。同时阳虚化气不足，气虚气滞，加上阴邪郁闭，导致郁热，形成了伏阳环境。在肿瘤恶化与转移的过程中，痰、湿、瘀、毒等阴邪与伏阳相互作用，最终导致肿瘤的迁移。基于此，提出了清郁热与散寒结相结合的肿瘤治法。 

Discussion on the Pathogenesis of Tumor Based on "Yang Transforming into Qi with Yin Constituting Form" and Fu-Yang Doctrine

The research on the pathogenesis of tumor has been a hot topic in the basic field of traditional Chinese medicine. Thus, the study combined with modern medical research results based on "yang transforming into qi with yin constituting form" and fu-yang doctrine to systematically explain the mechanism of tumor formation. It is believed that the formation and development of tumor may be related to the deficiency of yang with exuberance of yin in the body due to internal and external factors. That physique is prone to produce phlegm, dampness, stasis, toxin and other pathological products, which are similar to the concepts of hyperplasia, nodules and polyps in modern medicine. At the same time, the insufficient yang transforming into qi, and the deficiency and stagnation of qi, coupled with the stagnation of yin pathogens, lead to the constraint-heat resulting in fu-yang. In the process of tumor deterioration and metastasis, yin pathogens such as phlegm, dampness, stasis, and toxin interact with fu-yang and eventually lead to the migration of tumors. Based on this, we propose a treatment on tumor that combines clearing the constraint-heat with dispersing the cold accumulations.