| 以吲哚胺-2,3双加氧酶为靶点的肿瘤治疗研究进展 |
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| 引用本文： | 赵凌锋1,俸彦雁2,杨钰叠1,赵 赫1,杨琳琳1. 以吲哚胺-2,3双加氧酶为靶点的肿瘤治疗研究进展[J]. 现代肿瘤医学, 2022, 0(10): 1910-1914. DOI: 10.3969/j.issn.1672-4992.2022.10.041 |
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| 作者姓名： | 赵凌锋1 俸彦雁2 杨钰叠1 赵 赫1 杨琳琳1 |
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| 作者单位： | 1.昆明医科大学第三附属医院/云南省肿瘤医院/云南省癌症中心，云南 昆明 650100；2.临沧市第二人民医院，云南 临沧 677000 |
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| 摘 要： | 免疫逃逸已经成为肿瘤研究的一个新思路，吲哚胺-2,3双加氧酶（indoleamine-2,3 dioxygenase,IDO）是涉及色氨酸分解代谢的生物酶，在肿瘤中具有免疫逃逸的功能。IDO表达于不同肿瘤细胞中，并且和肿瘤的预后存在关联。目前，已有学者对IDO在癌症中的作用及IDO抑制剂进行深入探讨，发现在临床试验中IDO抑制剂显示出较好的药物代谢动力学特征和治疗效果，以及在癌症免疫治疗中的临床应用价值及意义。
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| 关 键 词： | 吲哚胺-2 3双加氧酶 吲哚胺-2 3双加氧酶抑制剂 癌症 免疫逃逸 治疗 |
Research progress of tumor therapy targeting indoleamine-2,3 dioxygenase |
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| ZHAO Lingfeng1,FENG Yanyan2,YANG Yudie1,ZHAO He1,YANG Linlin1. Research progress of tumor therapy targeting indoleamine-2,3 dioxygenase[J]. Journal of Modern Oncology, 2022, 0(10): 1910-1914. DOI: 10.3969/j.issn.1672-4992.2022.10.041 |
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| Authors: | ZHAO Lingfeng1 FENG Yanyan2 YANG Yudie1 ZHAO He1 YANG Linlin1 |
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| Affiliation: | 1.The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Yunnan Cancer Center，Yunnan Kunming 650100,China；2.Lincang Second People's Hospital,Yunnan Lincang 677000,China. |
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| Abstract: | Immune escape has become a research idea for tumor development.Indoleamine-2,3 dioxygenase (IDO) is a biological enzyme involved in tryptophan catabolism and has immune escape function in tumors.IDO is expressed in different cancer patients and has a close relationship with prognosis.At present,some scholars have conducted in-depth discussions on the role of IDO in cancer and IDO inhibitors,and found that IDO inhibitors show good pharmacokinetic characteristics and efficacy in clinical trials,and their clinical application and value in cancer immunotherapy. |
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| Keywords: | indoleamine-2 3 dioxygenase (IDO) indoleamine-2 3 dioxygenase inhibitor cancer immune escape treatment |
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