Use of indirect immunofluorescence in the lupus erythematosus/lichen planus overlap syndrome: An additional diagnostic clue |
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Authors: | Charles Camisa M.D. John C. Neff M.D. Richard G. Olsen Ph.D. |
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Affiliation: | Columbus, OH, USA |
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Abstract: | The lupus erythematosus (LE)/lichen planus (LP) overlap syndrome comprises a heterogeneous group of patients who demonstrate clinical, histologic, and immunopathologic characteristics of two diseases. We report six patients with the syndrome who were evaluated by a double-layer indirect immunofluorescence (IF) technic using patient serum and autologous lesional skin as substrate followed by conjugate. This test demonstrated intense staining of the stratum granulosum in two patients, a finding previously shown to be consistent with LP. A third patient developed criteria for the diagnosis of systemic LE with corroborating direct IF findings and a negative indirect IF assay. This preliminary study provides evidence for a possible way of distinguishing LE from LP in some patients with the overlap syndrome. |
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Keywords: | Reprint requests to: Dr. Richard G. Olsen Ohio State University Department of Veterinary Pathobiology 205 Goss Laboratory 1925 Coffey Rd. Columbus OH 43210. |
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