Temperature dependence of [3H]PAF binding to washed human platelets. |
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Authors: | P A Borea L Montesi A Muzzolini R Fantozzi |
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Affiliation: | Istituto di Farmacologia, Università di Ferrara, Italy. |
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Abstract: | Our results indicate that the binding of [3H]PAF to a single class of high affinity sites on human platelets is endothermic and largely entropy-driven. The increase in entropy can be attributed to the disorganization of water molecules bound to both receptor and ligand during the binding process. |
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