补肾健骨胶囊联合唑来膦酸注射液和碳酸钙D3治疗老年骨质疏松症的临床研究

目的探讨补肾健骨胶囊联合唑来膦酸注射液和碳酸钙D3片治疗老年骨质疏松症的临床疗效。方法选择2012年5月—2015年1月在郫县人民医院骨科接受医治的114例骨质疏松症患者为研究对象,所有患者按照治疗方法的不同分为对照组和治疗组,每组各57例。所有患者均口服碳酸钙D3片,1片/次,1次/d。在此基础上对照组静脉滴注唑来膦酸注射液,5 mg加入生理盐水250 m L中,1次/月,每次滴注不少于15 min。治疗组在对照组基础上口服补肾健骨胶囊,4粒/次,3次/d。两组患者均连续治疗12个月。观察两组患者的临床疗效,比较骨代谢指标以及骨密度(BMD)、骨钙素(BGP)、骨形态发生蛋白(BMP-2)及视觉模拟(VAS)评分。结果治疗后,对照组和治疗组总有效率分别为82.46%、94.74%,两组总有效率比较差异有统计学意义(P0.05)。治疗后,两组血钙(S-Ca)、血磷(S-P)明显增高,碱性磷酸酶(ALP)显著降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者L2-L4 BMD、股骨颈BMD、BGP、BMP-2均明显增加,VAS评分明显降低,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异有统计学意义(P0.05)。对照组、治疗组的不良反应发生率分别为7.02%、8.77%,两组不良反应发生率比较差异无统计学意义。结论补肾健骨胶囊联合唑来膦酸注射液和碳酸钙D3片治疗老年骨质疏松症具有较好的临床效果,可有效增加患者BMD,明显改善骨代谢,减少骨量流失,值得临床推广应用。

Clinical study of Bushen Jiangu Capsules combined with Zoledronic Acid Injection and calcium carbonate D3 in treatment of aged osteoporosis

Objective To investigate the clinical effect of Bushen Jiangu Capsules combined with Zoledronic Acid Injection and Calcium Carbonate D3 Tablets in treatment of aged osteoporosis.Methods Patients (114 cases) with aged osteoporosis in the Department of Orthopedics of Pixian County People''s Hospital from May 2012 to January 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control group (57 cases) and treatment group (57 cases). All patients were po administrated with Calcium Carbonate D3 Tablets, 1 tablet/time, once daily. The patients in the control group were iv administered with Zoledronic Acid Injection, 5 mg Zoledronic Acid Injection added into normal saline 250 mL, once monthly, and the infusion times were not less than 15 min. The patients in the treatment group were poadministered with Bushen Jiangu Capsules on the basis of the control group, 4 capsules/time, three times daily. The patients in two groups were treated for 12 months. After treatment, the efficacy was observed, and bone metabolic markers, BMD, BGP, BMP-2, and VAS scores in two groups before and after treatment were compared.Results After treatment, the efficacies in the control and treatment groups were 82.46% and 94.74%, respectively, and there were differences between two groups (P < 0.05). After treatment, S-P and S-Ca in two groups were significantly increased, but ALP was obviously decreased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). After treatment, L2-L4 BMD, femoral neck BMD, BGP, and BMP-2 in two groups were significantly increased, but VAS scores were obviously decreased, and the differences were statistically significant in the same group (P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P < 0.05). The incidences of adverse reactions in the control and treatment groups were 8.77% and 7.02%, , respectively, but there was no significant difference between two groups.Conclusion Bushen Jiangu Capsules combined with Zoledronic Acid Injection and Calcium Carbonate D3 Tablets has clinical curative effect in treatment of aged osteoporosis, can effectively increase BMD, significantly improve the bone metabolism, and reduce the loss of bone mass, which has a certain clinical application value.