| 注意缺陷型和混合型注意缺陷多动障碍儿童在Go/Nogo任务中的脑fMRI |
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| 引用本文： | 王梦星,雷都,张慧,张记磊,张凯华,马骏,杜小霞. 注意缺陷型和混合型注意缺陷多动障碍儿童在Go/Nogo任务中的脑fMRI[J]. 中国医学影像技术, 2016, 32(5): 678-682 |
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| 作者姓名： | 王梦星 雷都 张慧 张记磊 张凯华 马骏 杜小霞 |
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| 作者单位： | 华东师范大学物理系上海市磁共振重点实验室, 上海 200062,四川大学附属华西医院放射科华西磁共振研究中心, 四川 成都 610041,华东师范大学物理系上海市磁共振重点实验室, 上海 200062,华东师范大学物理系上海市磁共振重点实验室, 上海 200062,华东师范大学物理系上海市磁共振重点实验室, 上海 200062,上海交通大学医学院附属上海儿童医学中心发育行为儿科, 上海市儿科转化医学研究所, 上海 200127,华东师范大学物理系上海市磁共振重点实验室, 上海 200062 |
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| 基金项目： | 国家自然科学基金(81201082、81571658)、上海市科学技术委员会2014年医学引导类基金(14411969200)。 |
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| 摘 要： | 目的 探讨注意缺陷多动障碍(ADHD)注意缺陷型(ADHD-I)、混合型(ADHD-C)以及健康儿童在经典Go/Nogo抑制控制任务中脑功能激活的异同。方法 对19例ADHD-I(ADHD-I组)、21例ADHD-C(ADHD-C组)和25名健康儿童(HC组)进行Go/Nogo任务fMRI,采用SPM8软件处理功能数据,比较3组反应抑制和错误加工激活脑区的差异。结果 3组反应抑制差异的脑区主要位于左侧额下回和右侧额中回,ADHD-C在左侧额下回的脑激活水平高于ADHD-I(P<0.001);3组错误加工差异脑区主要位于右侧额上回,而ADHD-C组与ADHD-I组激活脑区差异无统计学意义(P=1.000)。结论 ADHD儿童在Go/Nogo任务中表现出的抑制控制脑功能受损,且ADHD-I和ADHD-C的反应抑制受损程度不同。
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| 关 键 词： | 注意缺陷多动障碍 脑 功能磁共振成像 |
| 收稿时间： | 2015-09-23 |
| 修稿时间： | 2016-01-28 |
Brain fMRI in combined and inattentive subtypes of attention deficit hyperactivity disorder during Go/Nogo task |
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| WANG Mengxing,LEI Du,ZHANG Hui,ZHANG Jilei,ZHANG Kaihu,MA Jun and DU Xiaoxia. Brain fMRI in combined and inattentive subtypes of attention deficit hyperactivity disorder during Go/Nogo task[J]. Chinese Journal of Medical Imaging Technology, 2016, 32(5): 678-682 |
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| Authors: | WANG Mengxing LEI Du ZHANG Hui ZHANG Jilei ZHANG Kaihu MA Jun DU Xiaoxia |
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| Affiliation: | Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China,Huaxi MR Research Center, Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China,Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China,Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China,Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China,Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children''s Medical Centre, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China and Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China |
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| Abstract: | Objective To compare the differences of brain function among children with combined attention deficit hyperactivity disorder (ADHD-C), inattentive ADHD (ADHD-I) and healthy controls during classical Go/Nogo task. Methods Totally 19 ADHD-I children (ADHD-I group), 21 ADHD-C children (ADHD-C group) and 25 healthy participants (HC group) underwent fMRI while performing the Go/Nogo task. Functional brain images were analyzed with the Statistical Parametric Mapping (SPM8) software. The activating brain area of response inhibition and error processing were compared among three groups. Results During response inhibition, significant differences of activating brain area among three groups were observed in left inferior frontal gyrus and right middle frontal gyrus, and ADHD-C group showed greater activation than ADHD-I group in inferior frontal gyrus (P<0.001). During error processing, significant differences of activating brain area among three groups were observed in right superior frontal gyrus, while there was no significant difference between ADHD-I group and ADHD-C group. Conclusion The children with ADHD-I and ADHD-C show dysfunctional inhibition control when performing Go/Nogo task, and the degree of dysfunctional inhibition control is different between ADHD-C and ADHD-I. |
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| Keywords: | Attention deficit disorder with hyperactivity Brain Functional magnetic resonance imaging |
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