纳米载体靶向肿瘤相关巨噬细胞治疗肿瘤新策略

肿瘤相关巨噬细胞(tumor associated macrophage,TAM)占实体肿瘤质量的50％左右,是肿瘤微环境的重要组成部分,能够促进肿瘤生长、刺激血管生成和抑制免疫反应等.将TAM作为治疗靶点,实现纳米载体在瘤内合理分布以及有效抑制肿瘤的目的,是新型纳米载体的研究方向.本文简述TAM在传递纳米载体方面的优势,列举药物靶向TAM治疗肿瘤的应用实例,阐明巨噬细胞介导的药物传递方式以及靶向TAM的治疗策略是未来治疗肿瘤的一个新方向.

Strategy of tumor associated macrophages as potential targets of nanocarrier for cancer therapy

Tumor associated macrophage (TAM) accounts for about 50% of the tumor mass. As an important part of the tumor microenvironment, TAM can promote tumor growth and metastasis. As a novel therapeutic target, TAM enables nanodrugs to achieve appropriate intratumoral biodistribution so as to effectively restrain the growth of tumor. This review summarized the characteristics and advantages of TAM that are related to the preferential capture of nanocarriers in the process of drug delivery, and illustrated the application of TAM as a therapeutic target, pointing out that macrophage-mediated delivery of nanodrugs as a potential strategy for oncotherapy in the future.