| 小檗碱调脂作用机制的研究进展 |
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| 引用本文： | 姜甜,贾友宏,李一石. 小檗碱调脂作用机制的研究进展[J]. 现代药物与临床, 2016, 31(5): 727-730. DOI: 10.7501/j.issn.1674-5515.2016.05.037 |
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| 作者姓名： | 姜甜 贾友宏 李一石 |
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| 作者单位： | 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 卫生部心血管药物临床研究重点实验室 临床药理中心,北京,100037 |
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| 基金项目： | "重大新药创制"科技重大专项(2012ZX09303-008-001);2010年国家临床重点专科建设项目 |
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| 摘 要： | 小檗碱是从黄连等植物中提取的一种异喹啉类生物碱,作为传统的抗炎、抑菌药物在临床应用已久。近年来研究发现其具有调脂作用,可通过调节肠道菌群结构、影响胆汁酸的合成与代谢、上调低密度脂蛋白受体(LDLR)的表达、激活内脏脂肪组织相关基因的表达、升高血清脂联素的表达、激活腺苷酸活化蛋白激酶(AMPK)途径、改善胰岛素抵抗等多个作用靶点发挥调脂作用,主要针对小檗碱的调脂作用及其机制进行综述。
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| 关 键 词： | 小檗碱 调脂作用 作用机制 |
| 收稿时间： | 2016-02-27 |
Research progress on lipid-regulating mechanism of berberine |
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| JIANG Tian,JIA You-hong and LI Yi-shi. Research progress on lipid-regulating mechanism of berberine[J]. Drugs & Clinic, 2016, 31(5): 727-730. DOI: 10.7501/j.issn.1674-5515.2016.05.037 |
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| Authors: | JIANG Tian JIA You-hong LI Yi-shi |
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| Affiliation: | Center for Clinical Pharmacology, Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health, Fuwai Hospital, National Center For Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China;Center for Clinical Pharmacology, Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health, Fuwai Hospital, National Center For Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China;Center for Clinical Pharmacology, Key Laboratory of Clinical Trial Research in Cardiovascular Drugs Ministry of Health, Fuwai Hospital, National Center For Cardiovascular Disease, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China |
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| Abstract: | Berberine is an isoquinoline alkaloid isolated from Coptis chinensis, and it is applied widely in clinic as a traditional anti-inflammatory and antibacterial drug for a long time. In recent years, it has been discovered that berberine still has lipid-regulating effects. Berberine plays the role of lipid-regulating by adjusting the structure of intestinal flora, influencing the synthesis and metabolism of bile acid, up-regulating the expression of low density lipoprotein receptor (LDLR), activating the expression of visceral adipose tissue related genes, elevating the expression of adiponectin, activating AMP-activated protein kinase (AMPK) pathways, and improving insulin resistance. This paper mainly summarizes the lipid-regulating function of berberine and its mechanisms of action. |
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| Keywords: | berberine lipid-regulating function mechanism of action |
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