CD4+/CD57+/CD69+ T lymphocytes and CD14+ dendritic cells accumulate in advanced follicular lymphoma |
| |
| Institution: | 1. Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia;2. Institute of Clinical Pathology and Cytology, Merkur University Hospital, Zagreb, Croatia;3. Department of Pathology and Cytology, University Hospital Centre Zagreb, Zagreb, Croatia;4. Department of Internal Medicine, Medical School Zagreb, University of Zagreb, Zagreb, Croatia;5. Division of Haematology, Department of Internal Medicine, Merkur University Hospital, Zagreb, Croatia;6. Department of Pathology, Medical School Zagreb, University of Zagreb, Zagreb, Croatia;1. Department of Oncology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350000, China;2. Department of Thoracic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350000, China;3. Molecular Oncology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350000, China;1. Department of Immunology, Medical University of Bialystok, 15-269 Bialystok, Poland;2. Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, 15-269 Bialystok, Poland;3. Otolaryngology and Maxillofacial Surgery Ward of the Provincial Integrated Hospital Jedrzej Sniadecki in Bialystok, 15-950 Bialystok, Poland;4. Department of Maxillofacial and Plastic Surgery, Medical University of Bialystok, 15-269 Bialystok, Poland;1. Department of Biotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India;2. Department of Clinical Pharmacology, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu 603203, India;1. Department of Emergency, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330038, China;2. Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330038, China;1. Department of Pediatrics, Zibo Central Hospital, No.54 Gongqingtuan West Road, Zhangdian District, Zibo 255036, Shandong, China;2. Scientific Research and Foreign Cooperation Department, Zibo Central Hospital, No.54 Gongqingtuan West Road, Zhangdian District, Zibo 255036, Shandong, China;1. Center for Interstitial and Rare Lung Disease, Department of Pneumology, Ruhrlandklinik University Hospital, University of Duisburg-Essen, Essen, Germany;2. Institute of Pathology, University Hospital Essen, Essen, Germany |
| |
| Abstract: | Follicular lymphoma is the second most frequent non-Hodgkin’s lymphoma, accounting for around 20 % of all lymphomas in Western countries. Initially, it behaves indolently, but in time becomes more aggressive and less susceptible to chemotherapy. Multiple features correlate with the survival of the patients and the progression of the disease, such as therapy with rituximab, tumour microenvironment and the intrafollicular proliferation index. Our research was focused on the association of specific components of tumour microenvironment and the tumour behaviour. The presence and the relative percentage of T lymphocytes, follicular dendritic cells, dendritic cells and macrophages was detected by immunohistochemical staining of the antigens specific for certain cell populations. Our results show that T lymphocytes and dendritic cells affect tumour growth, possibly through interactions with tumour cells. Higher patients’ ECOG score and the outcome of the disease are associated with the presence of CD14+ dendritic cells in tumour tissue, while the worse overall survival of patients is associated with the increased number of activated helper T lymphocytes that express marker of exhaustion CD57. Taken together, our results suggest that the efficiency of the immune response against follicular lymphoma depends on more than one type of immune cells. Also, we found that the phenotype of these cells, rather than just their number, affects the tumour behaviour and in consequence survival of the patients. |
| |
| Keywords: | Follicular lymphoma Tumour microenvironment T lymphocytes Exhausted phenotype Dendritic cells |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
