The CC ligand chemokine family members CCL17/CCL22 predict the survival and response to immune checkpoint blockade therapy of patients with head and neck squamous cell carcinoma |
| |
| Institution: | 1. Department of Oral Maxillofacial-Head Neck Oncology, Shanghai Ninth People''s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China;2. College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China;1. Department of Obstetrics and Gynecology, NYU Langone Health Long Island, Mineola, New York;2. Department of Radiation Oncology, NYU Grossman School of Medicine, New York, New York;3. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, NYU Langone Health, New York, New York;1. Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI;2. Geisel School of Medicine, Dartmouth College, Hanover, NH;3. Department of Radiation Oncology, The Ohio State University Wexner Medical Center, Columbus, OH;1. Division of Radiation Oncology, Department of Radiology, Siriraj Hospital, Mahidol University, Bangkok, Thailand;2. Division of Diagnostic Radiology, Department of Radiology, Faculty of medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;3. Division of Radiation and Oncology, Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;4. Gynecological Oncology Unit, Department of Obstetrics and Gynecology, Faculty of medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand;5. Diagnostic Radiology Unit, Department of Diagnostic and Therapeutic Radiology, Faculty of Medicine, Ramathibodi Hospital,, Mahidol University, Bangkok, Thailand;6. Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, Thailand;7. Abdominal Imaging Section, Department of Radiology, Faculty of Medicine Songklanagarind Hospital, Prince of Songkla University, Hat Yai, Songkhla, Thailand;8. Division of Therapeutic Radiology and Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital, Faculty of Medicine,Chulalongkorn University, Bangkok, Thailand;9. Division of Diagnostic Radiology, Department of Radiology, Kind Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;11. Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand;12. Center for Clinical Epidemiology and Clinical Statistics, Faculty of Medicine,, Chiang Mai University, Chiang Mai, Thailand |
| |
| Abstract: | Head and neck squamous cell carcinoma (HNSCC) is considered an immunosuppressive malignancy. Cross-talk between cancer cells and immune cells is modulated in part by CC ligand (CCL) chemokines, having a major effect on tumor progression. However, the predictive value and function of CCL family members in HNSCC have not been elucidated. Here, the predictive value of CCL members in cancer prognosis and Immune checkpoint blockade therapy response was investigated. CCL17 and CCL22 were screened as the key CCL chemokines in HNSCC through co-expression analysis. Further, the correlation between CCL17/CCL22 expression and cancer immune infiltration were evaluated based on TIMER and were validated by a set of scRNA-seq data. Moreover, the expression level of CCL17/CCL22 we evaluated to predict the response to Immune checkpoint blockade therapy in a panel of cancer types by using the TIDE database. Results indicated that CCL17/CCL22 had a high co-expression correlation and had a marginally statistical significance with the overall survival in HNSCC patients (P value = 0.057 and 0.055, respectively). Our findings showed high expression of CCL17/CCL22 was positively correlated with CD4+ T cell infiltration levels in HNSCCs and activate mTORC1 signaling pathway in CD4+ T cells. Further analysis from TIDE showed the high expression of CCL17/CCL22 might predict favorable responses to immune checkpoint blockade therapy in HNSCC patients. These findings provide an insight into the predictive roles of CCL17/CCL22 in HNSCC. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
