Mechanical thrombectomy with a novel device: initial clinical experience with the ANA thrombectomy device |
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Institution: | 1. Interventional Neuroradiology Section, Department of Radiology, Vall d''Hebron University Hospital, Barcelona, Spain;2. Stroke Unit, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Spain;3. Neurovascular Imaging Research Core and University of California Los Angeles Stroke Center, Department of Neurology, University of California, Los Angeles, CA, USA;4. Department of Neurology, Neurosurgery and Radiology, Emory University School of Medicine, Atlanta, GA, USA;5. Department of Neurology, UPMC, Pittsburgh, PA, USA;6. Departments of Radiology and Neurology, AZ Groeninge, Kortrijk, Belgium;7. Departments of Neuroradiology and Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden;8. Diagnostic and Therapeutic Neuroradiology, Hôpital Purpan, 31300, Toulouse, France;9. Department of Neurosurgery, University of Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA |
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Abstract: | IntroductionThe ANA? (Anaconda Biomed) thrombectomy system is a novel stroke thrombectomy device comprising a self-expanding funnel designed to reduce clot fragmentation by locally restricting flow while becoming as wide as the lodging artery. Once deployed, ANA allows distal aspiration in combination with a stentretriever (SR) to mobilize the clot into the funnel where it remains copped during extraction. We investigate safety and efficacy of ANA? in a first-in-man study.MethodsProspective data was collected on 35 consecutive patients treated as first line with ANA? at a single centre. Outcome measures included per-pass reperfusion scores, symptomatic intracerebral hemorrhage (sICH), NIHSS at day 5, and mRS at 90 days.ResultsMedian NIHSS was 12(9?18). Sites of primary occlusion were: 5 ICA, 15 M1-MCA, 15 M2-MCA. Primary performance endpoint, mTICI 2b-3 within 3 passes without rescue therapy was achieved in 91.4% (n = 32) of patients; rate of complete recanalization (mTICI 2c-3) was 65.7%. First pass complete recanalization rate was 42.9%, and median number of ANA passes 1(IQR: 1?2). In 17.1% (n = 6) rescue treatment was used; median number of rescue passes was 2(1–7), leading to a final mTICI2b-3rate of 94.3% (n = 33). There were no device related serious adverse events, and rate of sICH was 5.7% (n = 2). At 5 days median NIHSS was 1 (IQR 1?6) and 90 days mRS 0?2 was achieved in 60% of patients.ConclusionsIn this initial clinical experience, the ANA? device achieved a high rate of complete recanalization with a good safety profile and favourable 90 days clinical outcomes. |
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Keywords: | Mechanical thrombectomy Stroke New device |
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