Association of Cognitive Impairment With Mortality and Readmission in Patients With Heart Failure: A Meta-analysis |
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| Institution: | 1. Center of Clinical Medical Research, The Affiliated Suqian First People''s Hospital of Xuzhou Medical University, Suqian, Jiangsu, China;1. Institute of Molecular Biology & Translational Medicine, The Affiliated People''s Hospital, Jiangsu University, Zhenjiang, Jiangsu, China;1. Department of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland;2. Department of Cardiology and Intensive Care Medicine, Klinikum Wuerzburg Mitte, Wuerzburg, Germany;3. Division of Cardiology and Angiology II, Heart Center University of Freiburg, Bad Krozingen, Germany;1. NorthShore University HealthSystem, Evanston, Illinois;2. Department of Cardiology, NorthShore University HealthSystems, Evanston, Illinois;3. University of Chicago Pritzker School of Medicine, Chicago;4. Heriot-Watt University, Dubai;1. Cardiorespiratory Emergencies, Hospital General de México “Dr Eduardo Liceaga”, 06720, Mexico City, Mexico;2. Pulmonary Circulation Clinic, Hospital General de México “Dr. Eduardo Liceaga”, 06720, Mexico City, Mexico;3. Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico;4. Pulmonology Department, Hospital General de México “Dr. Eduardo Liceaga”, 06720, Mexico City, Mexico;5. Directorate of Research, Hospital General de Mexico “Dr. Eduardo Liceaga,” 06720, Mexico City, Mexico;6. I.M. Sechenov First Moscow State Medical University (Sechenov University), Department of Radiology, 119992, Moscow, Russia;7. Radiology Service, Hospital General de México “Dr Eduardo Liceaga”, 06720, Mexico City, Mexico;1. Division of Cardiovascular Disease, Loyola University Medical Center, Loyola Stritch School of Medicine, Maywood, IL;2. Brown University, Providence, RI;3. Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, OH;4. Mayo Clinic College of Medicine and Science, Department of Cardiovascular Medicine, Rochester, MN;5. Lifespan Cardiovascular Institute, Providence, RI;6. Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI;1. Department of Medicine, Miami Valley Hospital, Columbus, OH;2. Department of Medicine, University of Connecticut, Farmington, CT;3. Department of Cardiology, New York Medical College at Westchester Medical Center, New York, NY;4. Department of Cardiology, University of Kansas, Kansas City, KS;5. Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY;6. Department of Cardiology, Lehigh Valley Health Network, Allentown, PA;7. Department of Cardiology, Baylor College of Medicine, TX |
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| Abstract: | Cognitive impairment is a frequent condition in patients with heart failure (HF). This meta-analysis aimed to evaluate the prognostic impact of cognitive impairment on all-cause mortality and readmission among HF patients. We systematically searched articles indexing in PubMed and Embase databases until August 5, 2022. Original studies investigating the association of cognitive impairment with mortality and/or readmission for more than 3-month follow-up in patients with HF were selected. Twelve studies including 9556 patients were eligible. The prevalence of cognitive impairment ranged from 13.5% to 63.4% in HF patients. For patients with cognitive impairment vs those without, the pooled adjusted risk ratio (RR) was 1.88 (95% confidence intervals CI] 1.42-2.48) for all-cause mortality, 1.48 (95% CI 1.19-1.84) for readmission, and 1.53 (95% CI 1.35-1.73) for combined endpoints of all-cause mortality/readmission, respectively. Cognitive impairment is a significant predictor of all-cause mortality/readmission in patients with HF, even after adjustment for the conventional confounding. Evaluation of cognitive function may help to improve risk classification of HF patients. |
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