The Keystones of Right Ventricular Arrhythmogenic Cardiomyopathy-Induced Morphological Disarrangement |
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| Institution: | 1. Lecturer of Pathological Anatomy and Clinical Morphology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia;2. Scientific Director FSBI Research Institute of Human Morphology, Moscow, Russia;3. Head of Pathology Department, I. Javakhishvili Tbilisi State University, Tbilisi, Georgia;4. Histology Department, Yerevan State Medical University after M. Heratsi, Yerevan, Armenia;1. Miami Valley Hospital, Columbus, OH;2. Mount Sinai Morningside-West, Icahn School of Medicine at Mount Sinai, New York City, NY;3. University of Kansas, Kansas City, KS;4. Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY;5. New York Medical College at Westchester Medical Center, New York City, NY;6. Maharaja Jitendra Narayan Medical College, West Bengal, India;1. Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR;2. Department of Medicine, Forrest General Hospital, Hattiesburg, MS;3. Division of Cardiology, Department of Medicine, Duke University, Durham, NC;4. Division of Cardiology, Loma Linda University School of Medicine, Loma Linda, CA;5. Duke Clinical Research Institute, Durham, NC;1. Department of Cardiopulmonary Emergencies and Pulmonary Vascular Disorders Clinic, Hospital General de México “Dr Eduardo Liceaga,” Mexico City, Mexico;2. Department of Medicine, Divisions of Hospital and Adult Thrombosis Medicine, Texas Tech University Health Sciences Center and Paul L. Foster School of Medicine, El Paso, Texas, USA;3. Division of Cardiovascular Diseases, Texas Tech University Health Sciences Center and Paul L. Foster School of Medicine, El Paso, Texas, USA;4. Faculty of Medicine, National Autonomous University of Mexico (UNAM), Mexico City, Mexico;5. Department of Radiology, I.M. Sechenov First Moscow State Medical University (Sechenov?University), Moscow, Russia;6. Directorate of Research, Hospital General de Mexico “Dr Eduardo Liceaga,” 06720, Mexico City, Mexico;1. Department of Cardiology, St John of God Hospital, Budapest, Hungary;2. Department of Internal Medicine, Atrium Health Carolinas Medical Center, Charlotte, NC, USA;1. John Ochsner Heart and Vascular Institute, Ochsner Medical Center, New Orleans, LA;2. The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA;3. Division of Internal Medicine, Ochsner Medical Center, New Orleans, LA;4. Section of Cardiomyopathy & Heart Transplantation, John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New Orleans, LA |
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| Abstract: | Arrhythmogenic right ventricular cardiomyopathy is an urgent problem of modern cardiology. This myocardial remodeling manifests various desmosomopathies, channelopathies, and other mutations resulting in a violation of the coordinated heart work, particularly the myocardium. The incidence of this cardiomyopathy is not significant. Still, it is worth noting that athletes are at an increased risk of developing this disease, emphasizing the importance of studying this topic and its relevance from cardiologists and sports physicians. Moreover, the clinical pattern of this disease is heterogeneous. This pathology requires strengthening control and attention of medical personnel and constant improvement and optimization of diagnostic methods and treatment protocols. In this article, the pathophysiological mechanisms, molecular genetic aspects, and the dynamics of morphofunctional changes are represented in detail. Understanding the mechanisms of etiopathogenesis and the features of morphological changes observed in this cardiomyopathy and its more detailed study is fundamental in developing modern treatment methods to improve patients' quality and life expectancy. |
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