Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting,organized by the Spanish Association for the Study of the Liver (AEEH) |
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| Affiliation: | 1. Biomedical Research Network on Hepatic and Digestive Diseases (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain;2. SeLiver Group, Instituto de Biomedicina de Sevilla/Consejo Superior de Investigaciones Científicas (CSIC)/Universidad de Sevilla, Sevilla, Spain;3. Gastroenterology and Hepatology Department, Ramón y Cajal Hospital/Alcalá University/IIS Ramón y Cajal (IRYCIS), Madrid, Spain;4. UCM Digestive Diseases, Virgen del Rocío University Hospital, Sevilla, Spain;5. Program of Hepatology, Centre of Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain;6. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain;7. Gregorio Marañón Hospital, Madrid, Spain;8. IIS Gregorio Marañón (IiSGM), Madrid, Spain;9. Department of Medicine, Complutense University School of Medicine, Madrid, Spain;10. FISABIO – University Hospital Dr Peset, Valencia, Spain;11. Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain;12. Biomedical Research Network on Diabetes and Related Metabolic Diseases (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain;13. Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, Seville, Spain;14. University Pablo Olavide-University of Seville-CSIC, Seville, Spain;15. Clinical Medicine Department, Miguel Hernández University, San Juan De Alicante, Spain;p. IIS Isabial, Alicante General Hospital, Alicante, Spain;q. Liver Disease Lab, Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain;r. Exosomes Laboratory & Metabolomics Platform, Center for Cooperative Research in Biosciences (CIC bioGUNE), Derio, Spain;s. Basque Foundation for Sciences, Ikerbasque, Bilbao, Spain;t. Liver Unit, Hospital Clínic de Barcelona, IDIBAPS Biomedical Research Institute, Barcelona, Spain;u. Aparato Digestivo, Marqués de Valdecilla Hospital, Santander, Spain;v. Department of Immunology, Opthalmology and ENT, Complutense University School of Medicine, Madrid, Spain;w. Department of Internal Medicine III, University Hospital RWTH, Aachen, Germany;x. Biomedical Research Network on Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain;y. Department of Physiology, CIMUS, University of Santiago de Compostela, Spain;z. IIS Santiago de Compostela, Spain;11. Experimental Hepatology and Drug Targeting (HEVEPHARM) Group, University of Salamanca, IBSAL, Salamanca, Spain;22. Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain;33. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain;44. Liver Vascular Biology, IDIBAPS Biomedical Research Institute, Barcelona, Spain;55. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland |
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| Abstract: | This is a meeting report of the 3rd Translational Hepatology Meeting held in Alicante, Spain, in October 2021. The meeting, which was organized by the Spanish Association for the Study of the Liver (AEEH), provided an update on the recent advances in the field of basic and translational hepatology, with a particular focus on the molecular and cellular mechanisms and therapeutic targets involved in metabolic-associated fatty liver disease (MAFLD), metabolic-associated steatohepatitis (MASH), cirrhosis and end-stage hepatocellular carcinoma (HCC). |
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| Keywords: | MAFLD MASH Steatohepatitis Fibrosis Hepatocellular carcinoma Esteatosis Esteatohepatitis Fibrosis Carcinoma hepatocelular AEEH" },{" #name" :" keyword" ," $" :{" id" :" kw0055" }," $$" :[{" #name" :" text" ," _" :" Spanish Association for the Study of the Liver MAFLD" },{" #name" :" keyword" ," $" :{" id" :" kw0065" }," $$" :[{" #name" :" text" ," _" :" metabolic-associated fatty liver disease MASH" },{" #name" :" keyword" ," $" :{" id" :" kw0075" }," $$" :[{" #name" :" text" ," _" :" metabolic-associated steatohepatitis HCC" },{" #name" :" keyword" ," $" :{" id" :" kw0085" }," $$" :[{" #name" :" text" ," _" :" hepatocellular carcinoma T2DM" },{" #name" :" keyword" ," $" :{" id" :" kw0095" }," $$" :[{" #name" :" text" ," _" :" type 2 diabetes mellitus SM" },{" #name" :" keyword" ," $" :{" id" :" kw0105" }," $$" :[{" #name" :" text" ," _" :" metabolic syndrome HVPG" },{" #name" :" keyword" ," $" :{" id" :" kw0115" }," $$" :[{" #name" :" text" ," _" :" hepatic venous pressure gradient PH" },{" #name" :" keyword" ," $" :{" id" :" kw0125" }," $$" :[{" #name" :" text" ," _" :" portal hypertension LSECs" },{" #name" :" keyword" ," $" :{" id" :" kw0135" }," $$" :[{" #name" :" text" ," _" :" liver sinusoidal endothelial cells HSCs" },{" #name" :" keyword" ," $" :{" id" :" kw0145" }," $$" :[{" #name" :" text" ," _" :" hepatic stellate cells HFD" },{" #name" :" keyword" ," $" :{" id" :" kw0155" }," $$" :[{" #name" :" text" ," _" :" high fat diet ECM" },{" #name" :" keyword" ," $" :{" id" :" kw0165" }," $$" :[{" #name" :" text" ," _" :" extracellular matrix FXR" },{" #name" :" keyword" ," $" :{" id" :" kw0175" }," $$" :[{" #name" :" text" ," _" :" farnesoid X receptor TGR5" },{" #name" :" keyword" ," $" :{" id" :" kw0185" }," $$" :[{" #name" :" text" ," _" :" Takeda G protein-coupled receptor 5 BMI" },{" #name" :" keyword" ," $" :{" id" :" kw0195" }," $$" :[{" #name" :" text" ," _" :" body mass index DAMPS" },{" #name" :" keyword" ," $" :{" id" :" kw0205" }," $$" :[{" #name" :" text" ," _" :" damage-associated molecular patterns PAMPS" },{" #name" :" keyword" ," $" :{" id" :" kw0215" }," $$" :[{" #name" :" text" ," _" :" pathogen-associated molecular patterns MCJ" },{" #name" :" keyword" ," $" :{" id" :" kw0225" }," $$" :[{" #name" :" text" ," _" :" methylation-controlled J protein KCs" },{" #name" :" keyword" ," $" :{" id" :" kw0235" }," $$" :[{" #name" :" text" ," _" :" Kupffer cells TCA" },{" #name" :" keyword" ," $" :{" id" :" kw0245" }," $$" :[{" #name" :" text" ," _" :" tricarboxylic acid ROS" },{" #name" :" keyword" ," $" :{" id" :" kw0255" }," $$" :[{" #name" :" text" ," _" :" reactive oxygen species RNS" },{" #name" :" keyword" ," $" :{" id" :" kw0265" }," $$" :[{" #name" :" text" ," _" :" reactive nitrosative species superoxide radicals OH" },{" #name" :" keyword" ," $" :{" id" :" kw0285" }," $$" :[{" #name" :" text" ," _" :" hydroxyl radicals hydrogen peroxide radicals SOD" },{" #name" :" keyword" ," $" :{" id" :" kw0305" }," $$" :[{" #name" :" text" ," _" :" superoxide dismutase CAT" },{" #name" :" keyword" ," $" :{" id" :" kw0315" }," $$" :[{" #name" :" text" ," _" :" catalase GPX" },{" #name" :" keyword" ," $" :{" id" :" kw0325" }," $$" :[{" #name" :" text" ," _" :" glutathione peroxidase GST" },{" #name" :" keyword" ," $" :{" id" :" kw0335" }," $$" :[{" #name" :" text" ," _" :" glutathione-S-transferase SCFA" },{" #name" :" keyword" ," $" :{" id" :" kw0345" }," $$" :[{" #name" :" text" ," _" :" short chain fatty acids TLR" },{" #name" :" keyword" ," $" :{" id" :" kw0355" }," $$" :[{" #name" :" text" ," _" :" Toll-like receptor (TLR) PMBCs" },{" #name" :" keyword" ," $" :{" id" :" kw0365" }," $$" :[{" #name" :" text" ," _" :" peripheral mononuclear blood cells MAIT" },{" #name" :" keyword" ," $" :{" id" :" kw0375" }," $$" :[{" #name" :" text" ," _" :" mucosal-associated invariant T (MAIT) ihTh17" },{" #name" :" keyword" ," $" :{" id" :" kw0385" }," $$" :[{" #name" :" text" ," _" :" inflammatory hepatic T helper 17 EVs" },{" #name" :" keyword" ," $" :{" id" :" kw0395" }," $$" :[{" #name" :" text" ," _" :" extracellular vesicles DILI" },{" #name" :" keyword" ," $" :{" id" :" kw0405" }," $$" :[{" #name" :" text" ," _" :" drug-induced liver injury carbon tetrachloride |
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