Efficacy and Safety of OC-01 (Varenicline Solution) Nasal Spray on Signs and Symptoms of Dry Eye Disease: The ONSET-2 Phase 3 Randomized Trial |
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| Affiliation: | 1. Eye Research Foundation, Newport Beach, California;2. Vita Eye Clinic, Shelby, North Carolina;3. Piedmont Eye Center, Lynchburg, Virginia;4. Firma Clinical Research, Hunt Valley, Maryland;5. Oyster Point Pharma, Inc., Princeton, New Jersey |
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| Abstract: | |
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| Keywords: | Dry eye disease Nasal spray Nicotinic acetylcholine receptor Pharmacologic neuroactivator Phase 3 clinical trial Varenicline CAE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" controlled adverse environment CFS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" corneal fluorescein staining EDS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" eye dryness score ITT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" intention-to-treat logMAR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" logarithm of the minimum angle of resolution nAChR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" nicotinic acetylcholine receptor STS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" Schirmer test score TEAE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" treatment-emergent adverse event VNS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105v" }," $$" :[{" #name" :" text" ," _" :" varenicline solution nasal spray |
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