Human bone marrow mesenchymal stem cells-derived exosomes protect against nerve injury via regulating immune microenvironment in neonatal hypoxic-ischemic brain damage model |
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| Affiliation: | 1. Department of Pediatrics, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China;2. Department of Pediatrics, Zhongda Hospital, Southeast University, Nanjing 210009, Jiangsu, China;3. Department of Pediatrics, Jinling Hospital, the First School of Clinical Medicine, Southern Medical University, Nanjing 210093, Jiangsu, China;4. Department of Pediatrics, Jinling Hospital, Nanjing Medical University, Nanjing 210093, Jiangsu, China;1. Clinical Laboratory, The Rizhao People''s Hospital Affiliated to Jining Medical University, Rizhao, Shandong, China;2. Department of Blood Transfusion, The Rizhao People''s Hospital Affiliated to Jining Medical University, Rizhao, Shandong, China;3. Department of Medical Image, The Rizhao People''s Hospital Affiliated to Jining Medical University, Rizhao, Shandong, China;4. Department of Anesthesiology, The Rizhao People''s Hospital Affiliated to Jining Medical University, Rizhao, Shandong, China;1. Department of Trauma Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China;2. Department of School of Pharmacy, Nantong University, Nantong, Jiangsu, China;3. Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China;1. National Center of Medical Genetics, 146 Ave No 3102, Havana 11300, Cuba;2. Molecular Immunology Center. Havana, Cuba;3. National School of Public Health. Havana, Cuba;4. Ministry of Public Health, Havana, Cuba;1. Toxicology and Immunotherapy Research Unit, Department of Biochemistry, Alex Ekwueme Federal University Ndufu Alike, Nigeria;2. Department of Biochemistry, Rhema University, Aba, Nigeria;1. Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Vision Science, Nankai University Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, PR China;2. Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science, Tianjin Medical University Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, PR China;3. Department of Cell Biology, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, PR China;1. Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China;2. Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China;3. National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China;4. International Joint Research Center on Cell Stress and Disease Diagnosis and Therapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi, China |
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| Abstract: | Neonatal hypoxic-ischemic (HI) brain injury is a serious injury caused by various perinatal factors, which has become a heavy mental burden to the family. The molecular mechanism underlying neonatal hypoxic-ischemic brain injury remains largely unknown. Human bone marrow mesenchymal stem cells (hBMSCs) have caused wide public concern due to the immunomodulatory properties. Exosomes can polarize human microglia and thus changed it into an anti-inflammatory phenotype to reduce the release of pro-inflammatory factors. However, it is unclear whether hBMSCs-exosomes have effect on neonatal hypoxic-ischemic brain injury. In this study, we aimed at investigating the role of hBMSCs-exosomes in regulating immune response and nerve injury in neonatal hypoxic-ischemic brain damage model. In the research, we identified the exosome secretion of hBMSCs could transferred into human microglia (HMC). Moreover, we determined the importance of hBMSCs-exosomes in regulating HMC polarization and inflammatory response. Our research findings might provide a new insight into slowing the disease progression of neonatal hypoxic-ischemic brain injury. |
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| Keywords: | Exosomes Neonatal Hypoxic-ischemia brain damage Neuroinflammation Bone marrow mesenchymal stem cells |
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