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Association of Variants in IL6-Related Genes with Lung Cancer Risk in Moroccan Population
Authors:Kaanane  Houda  Senhaji  Nezha  Berradi  Hind  Benchakroun  Nadia  Benider  Abdellatif  Karkouri  Mehdi  El Attar  Hicham  IGOT CASA  Khyatti   Meriem  Nadifi   Sellama
Affiliation:1.Laboratory of Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, 20250, Casablanca, Morocco
;2.Oncology Department, Mohammed VI Center for Cancer Treatment, CHU Ibn Rochd, 20250, Casablanca, Morocco
;3.Anathomo-Pathology Department, CHU Ibn Rochd, 20250, Casablanca, Morocco
;4.Annasr Pathology Center, El Jadida, Morocco
;5.IGOT CASA: Inter Group of Thoracic Oncology, CHU Ibn Rochd, 20250, Casablanca, Morocco
;6.Oncovirology Laboratory, Institut Pasteur du Maroc, 20250, Casablanca, Morocco
;
Abstract:Purpose

Lung cancer is known to be a complex multifactorial disease, involving both genetic and environmental factors. The study of the different signaling pathways and the identification of the genes involved, will contribute to further understanding the pathogenesis of the disease, thus allowing the development of appropriate targeted treatments. Recently, the link between cancer and inflammation has become more evident and inflammation has been proposed as the seventh hallmark of cancer. Previous studies have suggested that key cytokines involved in inflammation may have an important role in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammation-related genes: IL-6, IL6-R, and IL6-ST, influence lung cancer risk in Moroccan population.

Materials and Methods

Single nucleotide polymorphisms (SNPs) in IL-6, IL6-R, and IL6-ST genes were assessed in 120 controls and 120 patients with confirmed lung cancer diagnosis. Genotyping analysis was performed with the TaqMan® allelic discrimination technology. The results were analyzed using SPSS 24.0 software.

Results

Among the studied SNPs, we found a significant association for the IL-6 (rs2069840) (OR = 1.63; 95% confidence interval 1.08–2.47; p = 0.01). No significant association was observed for the remaining SNPs of IL-6R (rs2228145) and IL-6ST (rs2228044) genes.

Conclusion

Our results suggest the IL-6 (rs2069840) polymorphism may influence the occurrence of lung cancer in Moroccan patients.

Keywords:
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