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Causal relationships between blood calcium,iron, magnesium,zinc, selenium,phosphorus, copper,and lead levels and multisystem disease outcomes in over 400,000 Caucasian participants
Institution:1. Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, China;2. Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China;3. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application,Guangxi Medical University, Nanning, Guangxi 530021, China;4. Department of Urology, Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China;5. Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;6. Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, Guangxi, China;7. Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;8. School of Public Health, Guangxi Medical University, Nanning, Guangxi, China;1. Research Platform Active Ageing, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;2. Centre for Sport Science and University Sports, University of Vienna, Auf der Schmelz 6, 1150 Vienna, Austria;3. Faculty of Life Sciences, Department of Nutritional Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria;4. Karl Landsteiner Institute for Remobilization and Functional Health/Institute for Physical Medicine and Rehabilitation, Kaiser Franz Joseph Hospital, Social Medical Center South, Vienna, Austria;1. Center for Translational Research in Aging & Longevity, Department of Health and Kinesiology, Texas A&M University, College Station, TX, United States;2. Pulmonary, Critical Care and Sleep Medicine, Scott and White Medical Center, College Station, TX, United States;1. Faculty of Physical Education, University of Brasília, Brasília, Brazil;2. Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, Maia, Portugal;3. Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Sydney, Australia;4. University of South Australia, Adelaide, Australia;5. Satellite Healthcare, San Jose, USA;1. Vascular Biology Program, Boston Children''s Hospital, Harvard Medical School, Boston, MA 02115, USA;2. Department of Surgery, Boston Children''s Hospital, Harvard Medical School, 300 Longwood Ave, Fegan 3, Boston, MA 02115, USA;3. Institutional Centers for Clinical and Translational Research, Boston Children''s Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA;4. Alcresta Therapeutics, Newton, MA 02462, USA;5. Animal Care Resources Children''s Hospital, Boston Children''s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA;6. Department of Pharmacy and the Division of Gastroenterology and Nutrition, Boston Children''s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA;1. Institute for Physical Activity and Nutrition, Deakin University, Geelong, Australia;2. Allied Health Department, Peter MacCallum Cancer Centre, Melbourne, Australia;3. Nutrition and Speech Pathology Department, Peter MacCallum Cancer Centre, Melbourne, Australia;4. Department of Nutrition, Dietetics and Lifestyle, HAN University of Applied Sciences, Nijmegen, the Netherlands;5. Department of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands;6. Institute for Intelligent Systems Research and Innovation, Deakin University, Waurn Ponds, VIC 3216, Australia;7. Physiotherapy Department, The University of Melbourne, Parkville, Australia;8. Department of Surgery, Western Health, The University of Melbourne, Parkville, Australia;9. Department of Nutrition and Dietetics, Western Health, Footscray, Australia
Abstract:
Keywords:Metal elements  Multisystem disease  Mendelian randomization
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