Association of rs12255372 in the TCF7L2
gene with type 2 diabetes mellitus: a meta-analysis |
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| Authors: | Jinjin Wang Jianfeng Zhang Linlin Li Yan Wang Qian Wang Yujia Zhai Haifei You Dongsheng Hu |
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| Affiliation: | 1.Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou, China;2.College of Public Health, Department of Epidemiology, Zhengzhou University, Henan, China;3.Henan Armed Police Corps Hospital, Zhengzhou, China;4.Shenzhen University School of Medicine, Shenzhen, China |
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| Abstract: | Our objective was to evaluate the association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus (T2DM) in the worldpopulation. We carried out a survey of the literature about the effect of rs12255372on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, andEmbase from 2006 to 2012, and then performed a meta-analysis of all the studies inorder to evaluate the association between rs12255372 and T2DM. A total of 33 articlesincluding 42 studies (with 34,076 cases and 36,192 controls) were confirmed to beeligible and were included in the final meta-analysis: 6 studies conducted onEuropeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans.Overall, the effect size was as follows: for the variant allele T (OR = 1.387, 95%CI= 1.351-1.424), for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GTgenotype (OR = 1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI= 1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). Insummary, by pooling all available qualified data from genetic studies on rs12255372and T2DM, we have confirmed that rs12255372 is significantly associated withsusceptibility to T2DM in the global population. |
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| Keywords: | Type 2 diabetes mellitus rs12255372 SNPs Meta-analysis |
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