| 细菌感染引起大鼠气道炎症的特征 |
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| 引用本文： | 熊密,许浒,吴焕明,郝春荣. 细菌感染引起大鼠气道炎症的特征[J]. 华中科技大学学报(医学版), 2001, 30(2): 93-96 |
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| 作者姓名： | 熊密 许浒 吴焕明 郝春荣 |
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| 作者单位： | 华中科技大学同济医学院基础医学院病理学教研室, |
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| 基金项目： | "九五”国家医学科技攻关基金资助项目(No.96-906-02-16) |
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| 摘 要： | 为探讨细菌感染引起大鼠气道炎症的特征,用鼻腔注入、反复感染肺炎克雷伯杆菌建立大鼠气道炎症模型.结果在炎症反应中,TNF-α含量增高出现较早且与炎症病变平行.炎性细胞开始为中性粒细胞,随后出现T淋巴细胞尤其是CD8细胞及树突细胞增多.提示在上述气道炎症过程中,T淋巴细胞尤其是CD8细胞起重要作用,而树突细胞能激活T淋巴细胞,TNF-α是中性粒细胞和T淋巴细胞在气道聚集和活化的重要因素.
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| 关 键 词： | 细菌感染 气道炎症 T细胞 大鼠 |
| 修稿时间： | 2000-09-18 |
The Character of Rat Airway Inflammation Induced by Bacteria Infection |
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| Xiong Mi,Xu Hu,Wu Huanming et al. The Character of Rat Airway Inflammation Induced by Bacteria Infection[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2001, 30(2): 93-96 |
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| Authors: | Xiong Mi Xu Hu Wu Huanming et al |
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| Affiliation: | Xiong Mi,Xu Hu,Wu Huanming et al Department of Pathology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | To explore the character of rat airway inflammation induced by bacteria infection, a rat airway inflammation model was established by repeatedly intranasal infection of klebsiella Pneumoniae. The results were showed that: in the inflammation process, the TNF-α content was increased early and parallel to inflammatory changes, Inflammatory cells were neutrophils at beginning followed by increased T lymphocytes (especially CD8 cells) and dendritic cells. It was suggested that in the process of airway inflammation, T lymphocytes (especially CD8 cells) played an important role, whereas dendritic cells could activate T lymphocytes. TNF-α is a important factor promoting collection and activation of neutrophils and T lymphocytes. |
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| Keywords: | bacterial infection airway inflammation T-cell rat |
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