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| SERPING1基因rs2511989多态性与年龄相关性黄斑变性相关性研究的Meta分析 | |
| 引用本文： | 秦宇,赵江月,潘春树,何雪菲,闵晓洁,王明武,阎启昌,吴迪,李晶,吴欣蔚,张劲松.SERPING1基因rs2511989多态性与年龄相关性黄斑变性相关性研究的Meta分析[J].国际眼科杂志,2015,15(6):944-949. |
| 作者姓名： | 秦宇 赵江月 潘春树 何雪菲 闵晓洁 王明武 阎启昌 吴迪 李晶 吴欣蔚 张劲松 |
| 作者单位： | 1. 中国医科大学附属第四医院眼科中国医科大学眼科医院辽宁省晶状体学重点实验室,中国辽宁省沈阳市,110005 2. 100088,中国北京市解放军第二炮兵总医院放射线科 3. 315000,中国浙江省宁波市第二医院眼科 4. 85711-1824,美国亚利桑那大学眼科与视觉科学院 |
| 基金项目： | 国家自然科学基金项目(No.81270988); 辽宁省高等学校科学研究一般项目(No.L2014305); 中国医科大学附属第四医院青年创新发展基金项目(No.YB1217) |
| 摘 要： | 目的:探讨经典通路SERPING1基因rs2511989基因多态性与年龄相关性黄斑变性(age-related macular degeneration,AMD)的相关性.方法:检索中国学术期刊网(CNKI)、PubMed、Cochrane、Embase以及Web of Science数据库,使用随机效应模型,使用OR值及其95％可信区间评价SERPING1 rs2511989基因多态性与AMD易感性的关联程度,同时对入选文献异质性,敏感性以及发表偏倚等进行评估.结果:共纳入15项病例对照研究,收集8657例AMD患者,对照组5393例.各个遗传模型中均未发现SERPING1基因多态性与AMD发病具有相关性.(显性模型:OR=0.960,95％ CI:0.918 ～1.003,P=0.009;隐性模型:OR=0.898,95％ CI:0.791 ～1.019,P=0.035;共显性纯合模型:OR=0.881,95％ CI:0.770 ～1.008,P=0.003;共显性杂合模型:OR=0.962,95％ CI:0.917 ～1.010,P=0.050).但进一步研究发现SERPING1基因多态性与新生血管型AMD显著相关.(显性模型:OR=0.691,95％ CI:0.547～0.872;共显性纯合模型:OR=0.661,95％ CI:0.450 ～0.971;共显性杂合模型:OR=0.754,95％ CI:0.589～0.964).亚组分析未发现种族与国家对rs2511989基因多态性与AMD有影响.结论:通常情况下SERPING1 rs2511989基因多态性与AMD无相关性,但在新生血管类型AMD可能与其存在相关性.期待更多研究来证实该假说. |
| 关 键 词： | 年龄相关性黄斑变性 SERPING1 基因多态性 Meta分析 |
| 收稿时间： | 2014/8/13 0:00:00 |
| 修稿时间： | 2015/1/25 0:00:00 |
Geneticpolymorphism of SERPING1 rs2511989 and age-related macular degeneration: a Meta-analysis |
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| Yu Qin,Jiang-Yue Zhao,Chun-Shu Pan,Xue-Fei He,Xiao-Jie Min,Ming-Wu Wang,Qi-Chang Yan,Di Wu,Jing Li,Xin-Wei Wu and Jin-Song Zhang.Geneticpolymorphism of SERPING1 rs2511989 and age-related macular degeneration: a Meta-analysis[J].International Journal of Ophthalmology,2015,15(6):944-949. | |
| Authors: | Yu Qin Jiang-Yue Zhao Chun-Shu Pan Xue-Fei He Xiao-Jie Min Ming-Wu Wang Qi-Chang Yan Di Wu Jing Li Xin-Wei Wu and Jin-Song Zhang |
| Institution: | Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Radiology, the Second Artillery General Hospital of PLA, Beijing 100088, China;Department of Ophthalmology, Ningbo No.2 Hospital, Ningbo 315000, Zhejiang Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology and Vision Science, the University of Arizona, Tucson, Arizona 85711-1824, USA;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China;Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, Shenyang 110005, Liaoning Province, China |
| Abstract: | AIM: To explore the association between the polymorphism rs2511989 in the classical pathway geneSERPING1(C1 inhibitor)and age-related macular degeneration(AMD). METHODS: A random-effect Meta-analysis was performed. An electronic search was done in CNKI, PubMed, the Cochrane Collaboration's Database, Embase, and the ISI Web of Knowledge. Odds ratios(OR)and their 95% confidence interval(CI)were calculated to assess the strength of association between SERPING1 rs2511989 polymorphism and AMD susceptibility. Heterogeneity, sensitivity analysis and publication bias were also tested. RESULTS: A total of 15 case-control studies with 8657 cases and 5393 controls were finally included in this Meta-analysis. There was no significant association between SERPING1 and AMD in all genetic models.(Dominant model: OR=0.960, 95%CI: 0.918-1.003, P=0.009; recessive model: OR=0.898, 95%CI: 0.791-1.019, P=0.035; homozygote model: OR=0.881, 95%CI: 0.770-1.008, P=0.003; heterozygote model: OR=0.962, 95%CI: 0.917-1.010, P=0.050). However, the associations between SERPING1 and neovascular AMD were significant in three models(dominant model: OR=0.691, 95%CI: 0.547-0.872; homozygote model: OR=0.661, 95%CI: 0.450-0.971; heterozygote model: OR=0.754, 95%CI: 0.589-0.964). Subgroup analysis by ethnicity and country did not find significant association between rs2511989 polymorphism and AMD susceptibility. CONCLUSION: SERPING1 rs2511989 does not associates with AMD generally but may associate with neovascular AMD. More studies are required to verify the hypothesis. |
| Keywords: | age-related macular degeneration SERPING1 polymorphism Meta-analysis |
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