| rasH2转基因小鼠与C57BL/6小鼠单次灌胃F3SM动力学参数比较 |
| |
| 引用本文： | 刘悦,孔琦,樊星,呼丹,董延生,马华智,吴纯启,钟武,王全军,丁日高.rasH2转基因小鼠与C57BL/6小鼠单次灌胃F3SM动力学参数比较[J].现代药物与临床,2015,38(3):279-283. |
| |
| 作者姓名： | 刘悦 孔琦 樊星 呼丹 董延生 马华智 吴纯启 钟武 王全军 丁日高 |
| |
| 作者单位： | 军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850;军事医学科医学院毒物药物研究所, 抗毒药物与毒理学国家重点实验室(军事医学科学院), 国家北京药物安全评价研究中心, 北京 100850 |
| |
| 基金项目： | 重大新药创制科技重大专项(2013ZX09302303, 2012ZX09301003-001-008) |
| |
| 摘 要： | 目的 比较C57BL/6小鼠(简称C57小鼠)和rasH2转基因小鼠(Tg rasH2小鼠)单次给予相同剂量受试药物F3SM后, 代谢动力学参数的差异, 观察两种动物对于F3SM的代谢动力学的一致性。方法 选用相同周龄的C57小鼠和Tg rasH2小鼠各4只, ig给予相同剂量(60 mg/kg)的F3SM羧甲基纤维素钠溶液。在给药后5、15、30 min及1、3、10、24 h各时间点进行采血, 采血量≥40 μL, 从血样中分离出10 μL血浆, 采用LC-MS/MS方法对样品的药物浓度进行检测, 用软件计算得出AUC(0-t)、MRT(0-t)、t1/2、Tmax和Cmax, 用配对t检验进行差异性分析。结果 对C57小鼠和rasH2转基因小鼠的AUC(0-t)、MRT(0-t)、t1/2、Tmax和Cmax进行配对t检验, 显示差异无显著性;二者药时曲线也大致相近。结论 单次给药后, C57小鼠和Tg rasH2小鼠对药物F3SM的代谢特征无显著差异, 提示C57小鼠与Tg rasH2小鼠对本药物的代谢特征相似, 提示在开展Tg rasH2小鼠研究中, 可首先采用C57小鼠进行毒性预探研究.
|
| 关 键 词： | 致癌性试验模型 Tg rasH2小鼠 C57小鼠 代谢动力学 |
| 收稿时间： | 2015/2/25 0:00:00 |
Comparison on pharmacokinetic parameters in blood of 2 species mouse after single ig administration of F3SM |
| |
| LIU Yue,KONG Qi,FAN Xing,HU Dan,DONG Yan-sheng,MA Hua-zhi,WU Chun-qi,ZHONG Wu,WANG Quan-jun and DING Ri-gao.Comparison on pharmacokinetic parameters in blood of 2 species mouse after single ig administration of F3SM[J].Drugs & Clinic,2015,38(3):279-283. |
| |
| Authors: | LIU Yue KONG Qi FAN Xing HU Dan DONG Yan-sheng MA Hua-zhi WU Chun-qi ZHONG Wu WANG Quan-jun and DING Ri-gao |
| |
| Institution: | National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;National Beijing Center for Drug Safety Evaluation and Research, State Key Laboratory of Toxicology and Medical Countermeasures (Academy of Military Medical Sciences), Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China |
| |
| Abstract: | |
| |
| Keywords: | carcinogenicity testing model rasH2 transgenic mice C57BL/6 mice pharmacokinetic |
|
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
|
