神经管缺陷产前筛查的AFP中位数倍数校正值的建立

目的 探讨和构建北京人群神经管缺陷(neural tube defect,NTD)产前筛查的血清标志物甲胎蛋白(α-fetoprotein,AFP)浓度中位数倍数(multiple of the median,MOM)的校正模型.方法 选取5668例孕中期孕妇,通过分析其AFP浓度与孕周和体重之间的相关性,分别进行回归...

Establishment of MOM Correction Models in NTD Prenatal Screening on IMMULITE 2000

Objective To establish appropriate correction models of multiple of the median of maternal serum marker α-fetoprotein for prenatal screening on patients with neural tube defect at the second trimester in Beijing China.Methods Data were collected from 5668 second-trimester pregnancies in Beijing of China,the correlation between AFP concentration and gestational age,maternal weight were analyzed by means of regression method respectively,regression functions for adjustment of MOM by gestational age and maternal weight were established for our own population.Results The regression relationships of AFP concentration and gestational age,maternal weight were established by exponential and power model for <35y group,S and quadratic model for ≥35y respectively.Before correction,a remarkable positive correlation(<35y:r=0.412,P=0.000;≥35y:r=0.435,P=0.000) existed between AFP concentration and gestational age,a remarkable negative correlation(<35y:r=-0.232,P=0.000;≥35y:r=-0.228,P=0.000) existed between MOM and maternal weight.After correction,there were no correlations between MOM and gestational age(<35y:r=0.446,P=0.911;≥35y:r=0.001,P=0.985),maternal weight(<35y:r=0.010,P=0.483;≥35y:-r=0.008,P=0.887).Conclusion The influence of gestational age and maternal weight on AFP concentration could be diminished by our correction models based on our own population.