C-反应蛋白与维持性血液透析患者贫血程度的相关性分析

目的探讨微炎症状态标志物C-反应蛋白与维持性血液透析患者贫血严重程度的关系。方法选择我院血透室行维持性血液透析、且透析时间在3～10个月的患者78例,透析当日空腹采血,测定超敏C反应蛋白(hs-CRP)、血红蛋白(Hb)。hs-CRP检测采用散射光比浊法,以3mg/L为界限,依据hs-CRP水平将患者分为hs-CRP正常组、hs-CRP增高组,比较两组间Hb和hs-CRP水平差异及hs-CRP水平与患者Hb水平的相关性及相关强度。结果 hs-CRP正常组和增高组血红蛋白的平均水平分别为95.8±18.7g/L、76.4±14.6g/L,hs-CRP正常组Hb明显高于hs-CRP增高组,两组之间差异具有统计学意义(P=0.0000.001)。单因素相关及回归分析显示,C-反应蛋白与血红蛋白呈负相关(r=-0.433,P=0.0000.001,回归系数(Beta)=-2.15。结论微炎症状态是维持性血液透析患者贫血的独立危险因素。

The Relationship Between C-reactive Protein and Anemia in Maintenance Hemodialysis Patients

Objective To explore the relationship between C-reactive protein and the severity of anemia in patients with maintenance hemodialysis. Methods The serum C-reactive protein （hs-CRP） and hemoglobin in 78 patients with 3-10 months maintenance dialysis were detected. According to the serum hs-CRP levels, the pa- tients were divided into hs-CRP normal group （with upper the limit of normal 3mg/L） and hs-CRP increased group. Results The mean serum hemoglobin levels in hs-CRP normal group and increased group were 95.8 ± 18.7 g/L and 76.4 ± 14.6g/L respectively. The serum hemoglobin levels in hs-CRP normal group was significantly higher than that of hs-CRP increased group （P 〈0.001 ）. The serum C-reactive protein was negatively correlated with serum hemoglobin （r = - 0. 433, P 〈 0. 001 ,β = - 2. 15 ）. Conclusion The micro-inflamma- tion state is the independent risk factor for anemia in patients with maintenance hemodialysis.