Production of transmitters stimulating antitumor cytostatic activity of bone marrow cells by activated lymphocytes |
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| Authors: | V. I. Seledtsov V. Ya. Taraban G. V. Seledtsova V. V. Senyukov D. M. Samarin E. A. Kashchenko V. A. Kozlov |
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| Affiliation: | (1) Institute of Clinical Immunology, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | Murine lymphocytes preactivated with mitogen (both T and B) produce soluble transmitters which stimulate cytostatic activity of normal mouse bone marrow cells, tested byin vitro inhibition of P815 mastocytoma and L1210 lymphoma cell growth. γ-Interferon is one of T-cell products stimulating antitumor activity of bone marrow cells. Cytostatic activity stimulated by T-cellular soluble transmitters is another characteristic of bone marrow cells isolated from nude mice. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 660–662, June, 1998 |
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| Keywords: | T, B lymphocyte bone marrow cell tumor growth inhibition |
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