| 局部脑缺血—再灌注大鼠的主动和被动回避行为障碍 |
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| 引用本文： | 李东亮,李玉书,程晓红,沈红. 局部脑缺血—再灌注大鼠的主动和被动回避行为障碍[J]. 河南医学研究, 1992, 0(2) |
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| 作者姓名： | 李东亮 李玉书 程晓红 沈红 |
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| 作者单位： | 新乡医学院基础医学部，中国军事医学科学院基础医学研究所，中国军事医学科学院基础医学研究所，新乡医学院基础医学部 河南省卫辉市 453100，100850，100850，河南省卫辉市 453100 |
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| 摘 要： | 用避暗法和穿梭箱法,研究了局部脑缺血一再灌注雄性 Wistar 大鼠的学习行为。脑缺血一再灌注损伤后3天,被动回避反应已有障碍,缺血一再灌注组的测验日潜伏期较假手术组显著缩短(P<0.05)。术后7天,缺血一再灌注组的回避反应少于假手术组,在训练的第1天尤其如此(P<0.01)。这些结果表明局部脑缺血一再灌注大鼠的两种学习行为均有损害,并提示这种大鼠可用作血管性痴呆的动物模型。
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| 关 键 词： | 局部脑缺血—再灌注 大鼠 学习记忆 痴呆模型 |
DISTURBANCE OF ACTIVE AND PASSIVE AVOIDANCE RESPONSE IN RATS WITH FOCAL CEREBRAL ISCHEMIA-REPERFUSION |
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| Li Dong-liang. DISTURBANCE OF ACTIVE AND PASSIVE AVOIDANCE RESPONSE IN RATS WITH FOCAL CEREBRAL ISCHEMIA-REPERFUSION[J]. Henan Medical Research, 1992, 0(2) |
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| Authors: | Li Dong-liang |
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| Abstract: | Learning behavior in adult male Wistar rats exposed to focal cerebral ischemia-reperfu sion were investigated in one-trial passive avoidance(step-through)and two-way active avoidance tasks (shuttle-box).Three days after cerebral ischemia-reperfusion,learning in one-trial passive avoidance tasks was disturbed.The latency on the test day in ischemia-reperfused rats was shorter than that in sham-operated rats(P<0. 05).Seven days after operation,the focal cerebral ischemia-reperfused rats were also impaired acquisition of two-way active avoidance response.The number of avoidance re- sponses in ischemia-reperfused rats were fewer than that in sham-operated ones,especially like that on the first day in training(P<0.01).Theses results suggest that rats with focal cerebral isehemia-reper- fusion are impaired in two different types of learning tasks,and may be useful as an animal model for the vascular type of dementia. |
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| Keywords: | Focal cerebral ischemia-reperfusion Rats Learning and memory Animal model for dementia |
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