Interleukin 18 receptor 1 gene polymorphisms are associated with asthma |
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| Authors: | Zhu Guohua Whyte Moira K B Vestbo Jorgen Carlsen Karin Carlsen Kai-Håkon Lenney Warren Silverman Michael Helms Peter Pillai Sreekumar G |
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| Affiliation: | 1Genetics, GlaxoSmithKline, Research Triangle Park, NC, USA. |
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| Abstract: | The interleukin 18 receptor (IL18R1) gene is a strong candidate gene for asthma. It has been implicated in the pathophysiology of asthma and maps to an asthma susceptibility locus on chromosome 2q12. The possibility of association between polymorphisms in IL18R1 and asthma was examined by genotyping seven SNPs in 294, 342 and 100 families from Denmark, United Kingdom and Norway and conducting family-based association analyses for asthma, atopic asthma and bronchial hyper-reactivity (BHR) phenotypes. Three SNPs in IL18R1 were associated with asthma (0.01131
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