| 哈尔滨市水源地江水对NIH3T3细胞的恶性转化作用 |
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| 引用本文： | 刘家仁,庞永旬,张尤恩,王贤珍,范春,付铁胜. 哈尔滨市水源地江水对NIH3T3细胞的恶性转化作用[J]. 中国公共卫生学报, 1999, 0(1) |
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| 作者姓名： | 刘家仁 庞永旬 张尤恩 王贤珍 范春 付铁胜 |
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| 作者单位： | 哈尔滨医科大学环境卫生学教研室，加拿大卡尔加里大学医学院卫生系，哈尔滨医科大学 |
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| 摘 要： | 用哈尔滨市水源地江水的３种有机提取物（乙醚，丙酮和二氯甲烷）分别做ＮＩＨ３Ｔ３细胞转化试验结果表明：３种有机提取物各剂量组均能诱发该细胞出现典型的细胞转化灶，其细胞转化率呈现剂量反应关系。转化细胞的恶性表现是生长失去接触性抑制并能在软琼脂内生长。提示该江水可能具有潜在的致癌作用。
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| 关 键 词： | 有机提取物，NIH3T3细胞，细胞转化 |
Induction of Malignant Transformation by Water in the Water Source of Harbin in NIH3T3 cell line |
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| Liu Jiaren,et al.. Induction of Malignant Transformation by Water in the Water Source of Harbin in NIH3T3 cell line[J]. , 1999, 0(1) |
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| Authors: | Liu Jiaren et al. |
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| Abstract: | NIH3T3cell line was used for the study transformation induction by organic extract(ether,acetone and dichlormethance from water in the water source of Harbin city.The result indicated that malignant transformed foci were induced by three organic extracts mentioned above and the cellular transformation frequencies presented a dose response relationship and determination of malignant cells disappeared in restraining of contact and grew in culture of soft agar while control cells did not.Thus,the present study demonstrates that three organic extract from water in water source of Harbin city has potential carcinogenesis. |
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| Keywords: | Organic extract NIH3T3 cell Cell transformation |
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