| ICAM-1和VCAM-1的表达与脑缺血再灌注损伤 |
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| 引用本文： | 王春燕,赵忠新,夏斌. ICAM-1和VCAM-1的表达与脑缺血再灌注损伤[J]. 中华神经医学杂志, 2003, 2(6): 453-455 |
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| 作者姓名： | 王春燕 赵忠新 夏斌 |
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| 作者单位： | 第二军医大学长征医院神经内科,上海,200003 |
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| 摘 要： | 本综述了近几年ICAM-1和VCAM-1的表达及其机制在脑缺血再灌注损伤方面的研究，认为ICAM-1和VCAM-1是与脑缺血再灌注损伤关系密切的细胞粘附分子，脑缺血再灌注损伤可导致ICAM-1及VCAM-1不同程度地表达增加，是主要通过NF-kB途径实现。有关其凋控机制及其抗体的临床应用有待进一步研究。
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| 关 键 词： | ICAM-1 VCAM-1 脑缺血 脑损伤 生物学 |
| 文章编号： | 1671-8925(2003)06-453-03 |
| 修稿时间： | 2003-03-25 |
Expressions of ICAM-1 and VCAM-1 associated with ischemia-reperfusion brain injury |
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| WANG Chunyan,ZHAO Zhongxin,XIA Bin. Expressions of ICAM-1 and VCAM-1 associated with ischemia-reperfusion brain injury[J]. Chinese Journal of Neuromedicine, 2003, 2(6): 453-455 |
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| Authors: | WANG Chunyan ZHAO Zhongxin XIA Bin |
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| Affiliation: | WANG Chunyan,ZHAO Zhongxin,XIA BinDepartment of Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China |
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| Abstract: | By suming up the recent progress in studying the expressions of ICAM-1 and VCAM-1 associated with ischemia-reperfusion brain injury, the authors in the paper argue that ICAM-1 and VCAM-1 are cell adhesion molecules in close relationship with ischemia-reperfusion brain injury which may to a different extent result in the expressive growth of ICAM-1 and VCAM-1 mainly via the path of NF-kB. The regulating mechanism and the clinical application of antibody need further research. |
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| Keywords: | ICAM-1 VCAM-1 expression ischemia-reperfusion brain injury |
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