白癜风病人的自身抗体检查

用间接免疫荧光法测定55例白癜风病人血清中ANA, AMA, ASMA, APCA, ATGA, ATMA 6种自身抗体.8例病人血清中查到1种以上抗体,阳性率14.5%,正常对照组55例中仅2例阳性,阳性率3.6%,两组间有显著差异(P<0.05).检出的自身抗体中,最多的是抗胃壁细胞抗体和抗甲状腺成分抗体.结合临床资料,说明部分白癜风病达的发病机制与自身免疫有关.

Autoantibodies in vitiligo

With the indirect immunofluorescent technique, circulating antibodies (ANA, AMA, ASMA, APCA, ATGA, ATMA) were tested in 55 patients with vitiligo. More than one antibodies can be demonstrated in 8 patients. The positive rate in patients with vitiligo was 14.5% as compared to 3.6% in normal control group in which 2 of the 55 persons tested were positive. There was significant difference between the 2 groups (P < 0.05),APCA and antithyroid antibody occurred most frequently in detected autoantibodies. In combination with the clinical data this result suggests that the pathogenesis of some patients with vitiligo be associated with autoimmunity.