银屑病E花环功能与E花环抑制因子的初步研究

本文测定51例寻常型银屑病患者E花环功能和血清E花环抑制因子(RIF),结果证实该病进行期患者EtRFC显著降低,而静止期和消退期患者EtRFC与正常对照组无显著差异,E花环功能缺陷与该病活动性有关.60拓进行期患者RIF阳性,其阳性率显著高于正常对照组.随着皮损消退,E花环功能恢复,RIF转阴.患者淋巴细胞经ConA短期孵育后E花环功能恢复,说明银屑病EtRFC减少是由于T细胞功能缺陷,而不是真正的T细胞数量减少.除RIF外.尚需考虑到其它抑制因素对银屑病E花环功能的影响.

Preliminary study on E rosette function and E rosette inhibitory factor in psoriasis

The results of detecting E rosette function and serum E rosette inhibitory factor(RIF)in 51 cases of psoriasis vulgaris showed that EtRFC decreased markedly in patients in progressive phase, whereas, there was no significant difference in inactive phase as compared with the normal group. The deficiency of E rosette function was related to the activity of the disease: The positive rate of RIF in patients in progressive phase was 60% and was much higher than that of the normal group. With remission of skin lesions E rosette function restored and RIF returned to negative. Suppression of E rosette function could be reversed by short term in vitro preincubatioa of patient's lymphocytes with ConA, which indicated that the decrease of EtRFC in the disease was caused by the defect of their function rather than the reduction of the number of T lymphocyte. Besides RIF. the effect of other inhibitory factors on E resette function on psoriasis should also be considered.