SLE患者尿抗核抗体组分的测定及其临床意义的探讨

本文从46例狼疮性肾病有大量蛋白尿和7例SLE无肾病和蛋白尿患者中进行血尿ANA及其组分ds-DNA抗体、Sm抗体和nRNP抗体的检测.结果肾病组血阳性率ANA 63%>ds-DNA抗体50>nRNP抗体37%>Sm抗体22.7%,尿阳性率nRNP抗体15.2%>ANA 13%>dsDNA抗体12.5%>Sm抗体6.8%,无肾病组阳性率血ANA100% >n-RNP抗体71.4>Sm抗体28.6%,尿只n-RNP抗体阳性14.3%.尿ANA组分阳性病例除1例外,余全在大量蛋白尿患者中检出.同时亦有一定量的IgG和IgA排出,血C₃值降低和CIC值增高.肾穿刺13例,ANA组分排出以膜型中最多,其次为膜增殖型和系膜增殖型.作者对SLE患者尿ANA组分检测的意义进行了阐明,最后指出从尿检出的重要性.

Determination of urinary antinuclear antibody and its clinical sigificance in SLE

This paper presents the determination of antinuclear antibodies and its specificities as ds-DNA antibodies, Sm antibodies and n-RNP antibodies of both blood and urine in 46 cases of lupus nephritis with heavy proteinuria and 7 cases of SLE without proteinuria. In the former group, the positive rate of blood was ANA 63%>ds-DNA antibodies 50%> n_RNP antibodies 37%>Sm antibodies 22.7%.