紫外线、补骨脂素加长波紫外线、境界线对皮肤接触过敏的影响

DNCB致敏豚鼠.分成3组,于背部一侧剃毛后皮肤分别应用治疗剂量UVR,GR照射、PUVA疗法,每周2-3次.共调.然后,于照射处和对称部位的非照射处皮肤进行DNCB激发试验和切取皮肤作Laagerhans细胞检查.结果表明:3种物理因子均可抑制DNCB引起的皮肤接触过敏反应.与此同时,Langerhans细胞的数量亦明显减少,试验的结果进一步证明皮肤接触过敏的发病与Langerhans细胞密切有关.同时提示了UVR,PUPA和GR可用于接触性过敏性皮炎的治疗.

Effects of UVR,PUVA and grenz ray on the experimental contact allergic reaction

Guinea pigs sensitized with DNCB were divided into 3 groups, and treated with UVR, PUPA, and grenz ray respectively on the shaved skin of one side of the back with usual therapeutic doses, 2-3 times weekly for three weeks.Then, the DNCB challenge test was made on the irradiated and unirradiated skin of the symmetric side.Then the biopsies of the skin were taken for the examination of Langerhans cells(LCs).The result showed that these three physical factors could suppress the contact allergic reaction of the irradiated skin, and at the same time the number of LCs decreased markedly. The result of the study further demonstrates that the pathogenesis of the contact allergy of the skin is closely related to LCs, and suggests that UVR, PUVA, and grenz ray can be used in the therapy of contact allergic dermatitis.