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不同月龄SPF级SD雌性大鼠主要脏器参数的研究
引用本文:王尧,唐大轩,葛麟,熊静悦,王莉,牟道华,梁娅君,谭正怀.不同月龄SPF级SD雌性大鼠主要脏器参数的研究[J].四川生理科学杂志,2009,31(4):155-156.
作者姓名:王尧  唐大轩  葛麟  熊静悦  王莉  牟道华  梁娅君  谭正怀
作者单位:1. 四川省中医药科学院药理毒理研究所,国家中医药管理局中药质量生物学评价重点研究室,四川成都,610041;成都中医药大学,四川成都,610075
2. 四川省中医药科学院药理毒理研究所,国家中医药管理局中药质量生物学评价重点研究室,四川成都,610041
摘    要:目的:探讨SD雌性大鼠的体重、脏器重量及其指数的正常值范围。方法:选用1月龄的雌性大鼠74只,分别于2、3、4、7、8月龄时测定其体重及10个主要脏器重量,并计算其脏器指数。结果:从2月龄至8月龄,雌鼠心,肝,肾,脑,肾上腺的重量均明显增长,而胸腺重量显著降低。然而由于体重增长等因素,其心、肝、脾、肺、肾、脑、胸腺以及肾上腺等指数均明显降低。结论:SPF级SD雌性大鼠主要脏器及其指数可反映其结构变化以及生理功能状态。

关 键 词:SD雌性大鼠  体重  脏器重量  脏器指数

Study on the parameters of main organs in SPF female Sprague Dawley rats in different ages
Wang Yao,Tang Da-xuan,Ge Lin,Xiong Jing-yue,Wang Li,Mu Dao-hua,Liang Ya-jun,Tan Zheng-huai.Study on the parameters of main organs in SPF female Sprague Dawley rats in different ages[J].Sichuan Journal of Physiological Sciences,2009,31(4):155-156.
Authors:Wang Yao  Tang Da-xuan  Ge Lin  Xiong Jing-yue  Wang Li  Mu Dao-hua  Liang Ya-jun  Tan Zheng-huai
Institution:1. Key Laboratory of biological evaluation of TCM quality of The SATCM, Institute of pharmacology and toxicology of the Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041;2. Chengdu University of Traditional Chinese Medicine, Chengdu 610075)
Abstract:Objective: To investigate the normal values of body weight, indexes and weight of organs in female Sprague Dawley (SD) rats in different ages. Methods: We measured the weight of body and organs in female Sprague Dawley rats at 2,3,4,7,8M old to calculate the indexes of organs. Results: From 2 monthes to 8 monthes, the weight of hearts, livers, kidneys, brains and adrenal glands increased, but the weight of thymus glands decreased in female rats. Meanwhile the indexes of hearts, livers, spleens, lungs, brains, thymus glands and adrenal glands reduced obviously as the body weight increased faster. Conclusion: In SPF female SD rats, the weight and indexes of the main organs can reflect its structure changes and conditions of physiological function.
Keywords:SPF female SD rat  Body weight  Organ weight  Organ index
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