| 伊曲康唑脂质体的制备工艺研究 |
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| 引用本文： | 董迪,刘红梅,宋笑丹,魏华,吴琳华.伊曲康唑脂质体的制备工艺研究[J].药学与临床研究,2008,16(2):79-82. |
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| 作者姓名： | 董迪 刘红梅 宋笑丹 魏华 吴琳华 |
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| 作者单位： | 哈尔滨医科大学附属第二医院药学部,哈尔滨,150086 |
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| 摘 要： | 目的:优化伊曲康唑脂质体的制备处方和工艺.方法:采用正交设计法,以伊曲康唑脂质体冻干粉重建包封率、粒径分布、渗漏率3个指标综合评分.结果:伊曲康唑脂质体的最佳工艺处方为药物-脂材比1∶30,胆固醇-磷脂比1∶5.5,去氧胆酸钠-脂材比1∶7,甘露醇和乳糖的用量为处方总重的60%,水合介质为磷酸盐缓冲液(pH=6.0),采用薄膜水化超声-冷冻干燥工艺制备.结论:按最优处方制得的脂质体的外观比较圆整,包封率和粒径均较好.
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| 关 键 词： | 伊曲康唑 脂质体 正交设计 |
| 文章编号： | 1673-7806(2008)02-79-04 |
| 收稿时间： | 2008/2/3 0:00:00 |
| 修稿时间： | 2008年2月3日 |
Preparation and optimization of itraconazole liposome |
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| DONG Di,LIU Hong-Mei,SONG Xiao-Dan,WEI Hua and WU Lin-Hua.Preparation and optimization of itraconazole liposome[J].Pharmacertical and Clinical Research,2008,16(2):79-82. |
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| Authors: | DONG Di LIU Hong-Mei SONG Xiao-Dan WEI Hua and WU Lin-Hua |
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| Institution: | Derpartment of Pharmcy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Derpartment of Pharmcy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Derpartment of Pharmcy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Derpartment of Pharmcy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China;Derpartment of Pharmcy, the Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China |
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| Abstract: | |
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| Keywords: | Itraconazole Liposome Orthogonal design |
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