| 亚甲基四氢叶酸还原酶基因多态性与脑血管疾病的研究 |
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| 引用本文： | 储照虎,刘永忠,杨本海,吴家幂. 亚甲基四氢叶酸还原酶基因多态性与脑血管疾病的研究[J]. 皖南医学院学报, 2001, 20(4): 253-255 |
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| 作者姓名： | 储照虎 刘永忠 杨本海 吴家幂 |
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| 作者单位： | 1. 附属弋矶山医院神经科,
2. 附属弋矶山医院临床医学研究所, |
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| 基金项目： | 院中青年科研启动基金(NO:WK200005)资助 |
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| 摘 要： | 目的 探讨N 亚甲基四氢叶酸还原酶 (MTHFR)基因多态性与脑血管疾病的关系。方法 利用聚合酶链反应和限制性片段长度多态性 (PCR RFLP)方法 ,检测了 72名健康人和 71名脑血管疾病患者MTHFR基因的6 77碱基多态性突变C→T情况 ,并加以对照分析。结果 脑血管疾病患者MTHFR基因突变型V6 77基因的频率 ,与正常健康人对比差异无显著意义 (P >0 .0 5 )。结论 MTHFR基因突变型V6 77基因可能是脑血管疾病的又一个遗传风险因子 ,但本研究结果显示与脑血管疾病的发病无关 ,是否为脑血管病的遗传风险因素有待进一步研究。
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| 关 键 词： | 亚甲基四氢叶酸还原酶基因 脑血管疾病 聚合酶链反应,多态性,限制性片段长度 |
| 修稿时间： | 2000-10-20 |
Relationship Between Methylenetetrahydrofolate Reductase Gene Polymorphism and Cerebral Vascular Disease |
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| Chu Zhaohu,Liu Yongzhong,Wu Jiami,et al. Relationship Between Methylenetetrahydrofolate Reductase Gene Polymorphism and Cerebral Vascular Disease[J]. Acta Academiae Medicinae Wannan, 2001, 20(4): 253-255 |
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| Authors: | Chu Zhaohu Liu Yongzhong Wu Jiami et al |
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| Abstract: | Objective To study the relationship between methylenetetrahydrofolate reductase(MTHFR)gene polymorphism and cerebral vascular disease(CVD).Methods By polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP),MTHFR 677C→T mutation was detected in 72 healthy controls and 71 patients with CVD.Results The frequency of MTHFR variant 677 of patients and that of healthy controls were similar(P>0.01).Conclusion MTHFR gene V677 mutation was found irrelevant to the genetic risk factors of cerebral vascular disease and has yet to be further studied. = |
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| Keywords: | methylenetetrahydrofolate reductase gene cerebral vascular disease polymerase chain reaction polymorphism restriction fragment length |
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