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| HPLC法测定盐酸氟桂利嗪口腔崩解片的含量 | |
| 引用本文： | 王景翔,牟微,曹德英,汤旭婷.HPLC法测定盐酸氟桂利嗪口腔崩解片的含量[J].中国当代医药,2011,18(11):5-6. |
| 作者姓名： | 王景翔 牟微 曹德英 汤旭婷 |
| 作者单位： | 1. 石家庄学院化工学院,河北石家庄,050035;河北医科大学药学院,河北石家庄,050017 2. 石家庄学院化工学院,河北石家庄,050035 3. 河北医科大学药学院,河北石家庄,050017 |
| 摘 要： | 目的：建立盐酸氟桂利嗪口腔崩解片的HPLC含量测定方法。方法：采用shimadzu ODS C18色谱柱（150.0 mm×4.6 mm,5μm）;流动相为甲醇-磷酸二氢钾（0.01 mol/L,pH=3.5）（68∶32）;流速为1.0 ml/min;检测波长为254 nm;柱温：30℃。结果：盐酸氟桂利嗪浓度为4.8～57.6μg/ml线性关系良好（r=0.999 9）;平均回收率为100.27%,RSD为1.00%（n=9）。结论：本方法简便、灵敏,精密度高,重现性好,可用于盐酸氟桂利嗪口腔崩解片的含量测定。 |
| 关 键 词： | 盐酸氟桂利嗪 口腔崩解片 高效液相色谱法 含量测定 |
HPLC Determination of Flunarizine Hydrochloride Orally Disintegrating Tablets |
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| Authors: | WANG Jingxiang MU Wei CAO Deying TANG Xuting |
| Institution: | 1.College of Chemical Engineering,Shijiazhuang University,Hebei Province,Shijiazhuang 050035,China;2.College of Pharmaceutical Sciences,Hebei Medical University,Hebei Province,Shijiazhuang 050017,China |
| Abstract: | Objective： To establish HPLC determination method of Flunarizine Hydrochloride orally disintegrating tablets. Methods： HPLC analysis was carried out by using shimadzu ODS C18 column （150.0 mm×4.6 mm, 5μm）. Mobile phase was methanol-potassium dihydrogen phosphate （0.01 mol/L, pH=3.5）（68：32）; The flow rate was 1.0 ml/min. The detection wavelength was set at 254 nm and the column temperature was 30℃. Results： There was a good linear relationship for flu- narizine hydrochloride in the range of 4.8-57.6 μg/ml（r=0.999 9）. The average recovery was 100.27% （n=9） and RSD was 1.00%. Conclusion： This method is simple, sensitive, and accurate with good reproducibility. It can be used for the content determination for Flunarizine Hydrochloride orally disintegrating tablets. |
| Keywords: | Flunarizine Hydrochloride Oral disintegrating tablets HPLC Content determination |
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