支气管哮喘患者外周血中IL-2﹑IL-4﹑IL-13和IgE的表达

目的：探讨哮喘患者外周血中IL-2、IL-4、IL-13和IgE的水平变化及临床意义。方法：抽取哮喘患者及正常对照组空腹静脉血2ml,采用双抗体夹心法（ELISA法）检测血清中IL-2、IL-4、IL-13和IgE的含量。结果：急性发作组和缓解组中IL-4、IL-13、IgE的含量明显高于正常对照组,差异有统计学意义（P〈0.01）,IL-2的含量低于正常对照组,差异具有统计学意义。急性发作组IL-4、IL-13、IgE高于缓解组,IL-2的含量低于缓解组,差异均具有统计学意义（P〈0.001）。结论：支气管哮喘患者外周血中IL-2、IL-4、IL-13和IgE水平的变化与支气管哮喘发病进程及临床诊治具有密切联系。

The expressions of serum IL-2, IL-4, IL-13 and IgE levels in patients with bronchial asthma

Objective： To explore the clinical significance of the changes of serum IL-2,IL-4,IL-13,IgE levels in patients with bronchial asthma.Methods： Fasting serum IL-2,IL-4,IL-13,IgE levels were measured with ELISA in patients with bronchial asthma as well as normal controls.Results： Serum IL-4,IL-13,IgE levels were significant higher in both acute attack group and remission stage group than normal controls （P0.001）.But the serum IL-2 level in acute attack group and remission stage group was vobiously lower than normal controls （P0.01）.Serum IL-4,IL-13,IgE levels in acute attack group were significant higher than remission stage group （P0.001）,but serum IL-2 was still lower than remission stage group （P0.001）.Conclusion： The changes of serum IL-2,IL-4,IL-13,IgE levels in patients with bronchial asthma have closely relationship with clinical diagnose and therapy,it is necessary to detect them in the different stages.