婴幼儿杯状病毒感染致多器官损害的临床特点分析

目的：探讨婴幼儿杯状病毒感染所致多器官损害的临床特点。方法：收集深圳市宝安区西乡人民医院收治的511例杯状病毒感染所致多器官损害患者的临床资料,对其进行回顾性分析。结果：511例杯状病毒感染患儿中神经系统受累最常见,其次为呼吸系统,其他依次为泌尿系统、肝脏和心脏。杯状病毒感染患儿较易发生多器官损害,以神经系统受累最常见,占89.63%;其中烦躁不安者占49.56%;萎靡不振者占23.80%;出现高热惊厥者占4.80%。其他器官损害较轻,其中肝功能损害占23.68%;尿常规及尿β2微球蛋白检查提示1.37%损害严重者引起肾功能的改变;21.92%患儿肌酸激酶同工酶（CK-MB）升高,34.25%肌酸激酶（CK）升高;13.31%患儿出现心电图检查异常;有呼吸系统症状者占42.86%。结论：杯状病毒感染引起小儿急性肠炎,同时可引起其他多系统和脏器损害,造成机体功能障碍。

Clinical analysis of human caliciviruse infection complicated with multiple organs injury

Objective： To study the clinical characteristics of human caliciviruse infection complicated with multiple organs injury.Methods： Restrospective analysis was performed on the clinical data of 511 cases of infant patients with human caliciviruse infection complicated with multiple organs injury in Xixiang People＇s Hospital in Baoan area of Shenzhe city.Results： In 511 cases of infant patients with human caliciviruse infection,among the involved organs,neurological system was the most frequently involved one,followed by respiratory system,the urinary system,liver and heart.Infant patients with human caliciviruse infection were predisposed to progress into multiple organs injury.Neurological system was the most frequently involved one,accounted for 89.63%;in which irritability accounted for 49.56%;malaise accounted for 23.80%;febrile seizures accounted for 4.80%.Minor damage to other organs,including liver damage 23.68%;Urine and urinary β2-microglobulin 1.37% of examinations showed severe damage can cause changes in renal function;21.92% increased in CK-MB,34.25% increased in CK;13.31% children with abnormal electrocardiogram;42.86% with respiratory symptoms.Conclusion： Calicivirus infection can cause acute enteritis,and other multi-system and organ damage,and cause dysfunction of the body.