| 异丙酚和七氟醚对老年乳腺癌患者术中应激反应和术后认知功能的影响 |
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| 引用本文： | 蔡淑女,方军.异丙酚和七氟醚对老年乳腺癌患者术中应激反应和术后认知功能的影响[J].全科医学临床与教育,2011,9(2):134-136. |
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| 作者姓名： | 蔡淑女 方军 |
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| 作者单位： | 浙江省肿瘤医院麻醉科,浙江杭州,310022 |
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| 摘 要： | 目的 探讨异丙酚和七氟醚麻醉对老年患者术中应激反应及术后认知功能的影响.方法 乳腺癌手术老年患者60 例,分别接受异丙酚(30 例)和七氟烷(30 例)麻醉,比较两组术中应激反应、术后简易精神状态量表评分、术后认知功能障碍发生率.结果 丙泊酚组在麻醉诱导后3 min皮质醇浓度明显低于入室后(t=2.15,P＜0.05);七氟醚组在麻醉诱导后3 min、插管后1 min、切皮后2 min、关腹后及拔管后皮质醇浓度均高于入室后(t分别=2.25、2.13、1.98、2.99、3.15,P均＜0.05);七氟醚组各时间点的血液中皮质醇浓度均高于丙泊酚组(t分别=3.21、2.95、3.42、3.55、3.54,P均＜0.05);丙泊酚组术后认知功能障碍发生率为6.70%,七氟醚组为13.30%,两组比较,差异有统计学意义(χ2=50.28,P＜0.05).结论 丙泊酚能有效抑制全麻术中应激反应,两组均可引起老年患者术后早期短暂的认知功能下降,但异丙酚较七氟烷能减少认知功能障碍的发生率.
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| 关 键 词： | 丙泊酚 七氟醚全麻 应激反应 认知功能 老年 |
Effect of propofol and sevoflurane on surgical stress response and postoperative cognitive function in elderly breast carcinoma patients |
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| CAI Shunv,FANG Jun.Effect of propofol and sevoflurane on surgical stress response and postoperative cognitive function in elderly breast carcinoma patients[J].clinical education of general practice,2011,9(2):134-136. |
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| Authors: | CAI Shunv FANG Jun |
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| Institution: | CAI Shunv,FANG Jun.Department of Anesthesiology,Zhejiang Cancer Hospital,Hangzhou 310022,China |
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| Abstract: | Objective To investigate the effect of propofol and sevoflurane on surgical stress response and postoperative cognitive function in elderly patients. Methods Sixty elderly patients scheduled for breast carcinoma radical operation with general anesthesia were equally into propofol group and sevoflurane group. The surgical stress response postoperative mini-mental state examination (MMSE) and the rate of postoperative cognitive dysfunction (POCD) were compared between the two groups. Results Blood cortisol of... |
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| Keywords: | propofol sevoflurane stress response cognitive function elderly patients |
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