| 尿毒症患者继发医院感染及病原菌耐药性分析 |
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| 引用本文： | 樊雪芳,翁明祥.尿毒症患者继发医院感染及病原菌耐药性分析[J].全科医学临床与教育,2011,9(3):283-285,288. |
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| 作者姓名： | 樊雪芳 翁明祥 |
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| 作者单位： | 衢州市人民医院血透室,浙江衢州,324000 |
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| 摘 要： | 目的针对衢州市人民医院尿毒症患者继发医院感染的病原菌特点以及对常见抗菌药物的耐药情况进行研究,以指导临床合理用药和医院控制感染。方法对55例尿毒症继发医院感染患者的致病菌进行分离及鉴定。针对分离到的致病菌采用K-B法测定常见抗菌药物的耐药性。并采用超广谱β-内酰胺酶(ESBLs)纸片筛选法和酶抑制剂增强试验确证法筛选产ESBLs的肠杆菌科细菌。采用微量平板稀释法及PCR法筛选并确定对甲氧西林耐药的金黄色葡萄球菌(MRSA)菌株。采用琼脂稀释法筛选耐万古霉素肠球菌(VRE)。结果 55例尿毒症继发医院感染患者共培养到46株病原菌,其中革兰阴性杆菌(占67.39%)明显高于革兰阳性球菌(占23.91%)。分离到的大肠埃希菌及肺炎克雷伯菌菌株中产ESBLs菌株数均为6株,分别占60.00%及46.15%,均对碳青霉烯类抗生素敏感。分离到3株MRSA菌株,未分离到VRE菌株。结论本院尿毒症继发医院感染病原体分布以革兰阴性菌为主,产ESBLs菌株及MRSA菌株分离率较高,细菌耐药情况较严重。
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| 关 键 词： | 尿毒症 医院感染 耐药性 超广谱β-内酰胺酶 甲氧西林耐药金黄色葡萄球菌 |
Antibiotics resistance of hospital infection pathogens in uremia patients |
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| FAN Xuefang,WEN Mingxiang.Antibiotics resistance of hospital infection pathogens in uremia patients[J].clinical education of general practice,2011,9(3):283-285,288. |
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| Authors: | FAN Xuefang WEN Mingxiang |
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| Institution: | FAN Xuefang,WEN Mingxiang.Hemodialysis Room,Quzhou People's Hospital,Quzhou 324000,China |
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| Abstract: | Objective To study the characteristics and antibiotics resistance of the hospital infection pathogens in uremia patients,to direct the appropriate antibiotics use in clinic and hospital infection control.Methods Hospital infection pathogens were isolated and identified among 55 uremia patients.The resistance of antimicrobial agents against isolated pathogens was determined by K-B method.ESBLs-producing enterobacteriaceae isolates were detected by screening and confirmatory tests for ESBLs.Micro plate diluti... |
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| Keywords: | uremia hospital infection resistance extended-spectrum β-lactamases methicillin-resistant staphy-lococcus aureus |
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