2型糖尿病与非糖尿病患者腰椎骨髓脂肪分数值定量比较

目的 比较2型糖尿病(type 2 diabetes mellitus, T2DM)与非糖尿病患者腰椎骨髓脂肪含量。方法 前瞻性选择行腰椎MRI检查的患者100例，均采用磁共振非对称回波最小二乘估算法迭代水脂分离(water and fat with Echo Asymmetry and Least squares estimation, IDEAL)序列扫描。测量腰椎骨髓IDEAL-fat、IDEAL-water信号值，计算腰椎骨髓脂肪分数值(bone marrow fat fraction, BMFF_IDEAL)。比较T2DM组和非糖尿病组腰椎骨髓IDEAL-fat、IDEAL-water平均信号值、BMFF_IDEAL值，并分析与性别、年龄、体重指数(body mass index, BMI)及糖化血红蛋值的关系。结果 T2DM组、非糖尿病组腰椎骨髓IDEAL-fat和IDEAL-water平均信号值差异无统计学意义(P>0.05),T2DM组腰椎骨髓BMFF_IDEAL值高于非糖尿病组(P<0.05)。T...

Quantitative analysis of lumbar bone marrow fat content in patients with type 2 diabetes mellitus and non-diabetic patients

Objective To compare the bone marrow fat(BMF) content of lumbar spine between type 2 diabetes mellitus(T2DM) patients and non-diabetic patients.Methods We conducted a prospective analysis of 100 patients who underwent lumbar MRI iterative decomposition of water and fat with echo asymmetry and least-squares estimation(IDEAL) sequence. The IDEAL-fat and IDEAL-water signal values of lumbar bone marrow were measured. The BMF fraction(BMFFIDEAL) was calculated. The difference of mean IDEAL-fat signal value, mean IDEAL-water signal value and the BMFFIDEAL value of lumbar bone marrow between T2DM group and non-diabetic group were compared, and their correlation with age, gender, body mass index(BMI) and glycated hemoglobin A 1c(HbAlc) were analyzed.Results There was no significant difference in the mean IDEAL-fat signal value and mean IDEAL-water signal value of lumbar bone marrow between T2DM group and non-diabetic group(P＞0.05). The BMFFIDEAL value of lumbar bone marrow in T2DM group was higher than that in non-diabetic group(P＜0.05). There was no significant difference in the BMFFIDEAL value of lumbar bone marrow between male and female group, and between normal group and overweight group in T2DM group(P＞0.05), as well as in non-diabetic group(P＞0.05). There was no significant difference in the IDEAL-fat value among L1-L5 in both T2DM group and non-diabetic group(P＞0.05). There was significant difference in the IDEAL-water value and BMFFIDEAL value among L1-L5 in both T2DM group and non-diabetic group(P＜0.05). The BMFFIDEAL value of L1 of bone marrow was lower than that of L3 in T2DM group. The IDEAL-water value of L1 was higher than that of L3， and BMFFIDEAL value of L1 was lower than that of L3and L4 in non-diabetic group(P＜0.05). The BMFFIDEAL value of lumbar bone marrow was positively correlated with age in T2DM group and non-diabetic group. The BMFFIDEAL value of lumbar bone marrow was positively correlated with HbAlc value in T2DM group(P＜0.05).Conclusion The BMF content of lumbar spine in T2DM patients was higher than that in non-diabetic patients, which is associated with age and HbAlc, but not related to gender and BMI.