通肺平哮汤联合糖皮质激素吸入对支气管哮喘患儿肺功能与炎性因子水平的影响

目的 探究通肺平哮汤联合糖皮质激素吸入对支气管哮喘患儿血清炎性因子与肺功能的影响。方法 选取2020年4月至2022年4月榆林市中医医院收治的支气管哮喘患儿104例,随机分为对照组（52例,糖皮质激素治疗）、中西医结合组（52例,糖皮质激素+通肺平哮汤治疗）,观察两组患儿治疗效果、记录症状消失/缓解时间、治疗前后肺功能与血清炎性因子水平、不良反应发生情况。结果 中西医结合组治疗总有效率显著高于对照组（P<0.05）;中西医结合组肺部哮鸣音消失、喘憋消失、肺部湿啰音消失、咳嗽缓解时间均显著短于对照组（P<0.05）;治疗后中西医结合组肺功能指标[用力呼气容积（forced vital capacity,FVC）、第1秒用力呼气容积（forced expiratory volume in one second,FEV₁）,第1秒用力呼气容积与用力呼气容积比值（FEV₁/FVC）]均显著高于对照组（P<0.05）;治疗后中西医结合组血清白三烯（leukotriene,LT）水平显著低于对照组,干扰素-γ（interferon-γ,INF-γ）水平显著高于对照组（P<0.05）;两组不良反应发生率比较差异无统计学意义（P>0.05）。结论 通肺平哮汤联合糖皮质激素吸入治疗支气管哮喘可显著降低患儿血清炎性因子水平,促进临床症状缓解,改善患儿肺功能,提高整体疗效,且安全性高。

Effects of Tongfei Pingxiao Decoction combined with glucocorticoid inhalation on pulmonary function and inflammatory factor levels in children with bronchial asthma

Objective To explore the effect of Tongfei Pingxiao Decoction combined with glucocorticoid inhalation on serum inflammatory factors and pulmonary function in children with bronchial asthma.Methods A total of 104 children with bronchial asthma who were admitted to Yulin Hospital of Traditional Chinese Medicine from April 2020 to April 2022 were collected and randomly divided into the control group （52 cases, glucocorticoid treatment） and the integrated traditional Chinese and Western medicine group （52 cases, glucocorticoid treatment + Tongfei Pingxiao Decoction）. The treatment effect, symptom disappearance/relief time, pulmonary function and serum inflammatory factor levels before and after treatment, and the occurrence of adverse reactions were observed in the two groups.Results The total effective rate of treatment in the integrated traditional Chinese and Western medicine group was significantly higher than that in the control group （P<0.05）; the disappearance of lung wheezing, wheezing, lung crackles, and cough relief time in the integrated traditional Chinese and Western medicine group were significantly shorter than those in the control group （P<0.05）. After treatment, the pulmonary function indexes [forced expiratory volume （FVC）, forced expiratory volume in 1 second （FEV₁）, ratio of forced expiratory volume in 1 second to forced expiratory volume （FEV₁/FVC）] of integrated traditional Chinese and Western medicine group were significantly higher than those in the control group （P<0.05）; after treatment, the serum leukotriene （LT） level in the integrated traditional Chinese and Western medicine group was significantly lower than that in the control group, and the level of interferon-γ （INF-γ） was significantly higher compared with the control group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two group （P>0.05）.Conclusion Tongfei Pingxiao Decoction combined with glucocorticoid inhalation in the treatment of bronchial asthma can significantly reduce the level of serum inflammatory factors in children, promote the relief of clinical symptoms, improve the lung function of children, and improve the overall curative effect with high safety.