肺癌脑转移MRI影像基因组学研究进展

脑转移瘤是发病率高且预后差的颅内恶性肿瘤,以肺癌脑转移在临床中最为常见。MRI作为颅内肿瘤首选影像诊断方法,MRI影像基因组学逐步应用于脑转移瘤的精准个体化诊疗。伴随着对基因与肿瘤之间联系的不断深入研究,肿瘤的诊断正向分子遗传学方向延伸,影像基因组学是一种将影像表型与基因分子融合的方法,运用无创精准的方式检测活体肿瘤的分子遗传学改变,在肿瘤的发现、指导治疗及预后预测等方面已广泛应用。现基于颅脑的MRI图像,对影像基因组学在肺癌脑转移应用的可行性及研究进展予以综述。

Developments on radiogenomics based on MRI in lung cancer brain metastases

Brain metastases are intracranial malignant tumors with high incidence and poor prognosis, brain metastases from lung cancer are the most common in clinical practice. MR is the preferred imaging diagnosis method for intracranial tumors, and MRI imagingomics is gradually applied to the precise and individualized diagnosis and treatment of brain metastases. With the continuous in-depth research on the connection between genes and tumors, tumor diagnosis is extended to the direction of molecular genetics. Radiogenomics is a method of fusing imaging phenotypes with genes and molecules, using non-invasive and accurate methods to detect tumors. The molecular genetic changes of the disease have been widely used in tumor discovery, treatment guidance and prognosis prediction, etc. This article reviews the feasibility and research progress of MRI radiogenomics radio genomics in brain metastases.