Global Burden of Invasive Nontyphoidal Salmonella
Disease, 2010 |
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| Authors: | Trong T. Ao Nicholas A. Feasey Melita A. Gordon Karen H. Keddy Frederick J. Angulo John A. Crump |
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| Affiliation: | Centers for Disease Control and Prevention, Atlanta, Georgia, USA (T.T. Ao, F.J. Angulo, J.A. Crump); ;Liverpool School of Tropical Medicine, Liverpool, UK (N.A. Feasey); ;Malawi–Liverpool–Wellcome Trust Clinical Research Programme, Blantyre, Malawi (N.A. Feasey, M.A. Gordon); ;University of Liverpool, Liverpool (M.A. Gordon); ;National Health Laboratory Service, Johannesburg, South Africa (K.H. Keddy); ;University of Otago, New Zealand (J.A. Crump) |
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| Abstract: | Nontyphoidal Salmonella is a major cause of bloodstream infectionsworldwide, and HIV-infected persons and malaria-infected and malnourished childrenare at increased risk for the disease. We conducted a systematic literature review toobtain age group–specific, population-based invasive nontyphoidalSalmonella (iNTS) incidence data. Data were categorized by HIVand malaria prevalence and then extrapolated by using 2010 population data. Thecase-fatality ratio (CFR) was determined by expert opinion consensus. We estimatedthat 3.4 (range 2.1–6.5) million cases of iNTS disease occur annually (overallincidence 49 cases [range 30–94] per 100,000 population). Africa, whereinfants, young children, and young adults are most affected, had the highestincidence (227 cases [range 152–341] per 100,000 population) and number ofcases (1.9 [range 1.3–2.9] million cases). An iNTS CFR of 20% yielded 681,316(range 415,164–1,301,520) deaths annually. iNTS disease is a major cause ofillness and death globally, particularly in Africa. Improved understanding of theepidemiology of iNTS is needed. |
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| Keywords: | bacteremia Salmonella incidence global burden invasive disease nontyphoidal Salmonella disease bacteria |
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