Clinicopathological and prognostic significance of p53, Ki-67, and Bcl-2 expression in Tunisian gastric adenocarcinomas |
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| Affiliation: | 1. Center of Biotechnology of Sfax, University of Sfax, BP K 3018, Sfax, Tunisia;2. Department of Anatomy-Pathology, Habib Bourguiba Hospital, Sfax, Tunisia;3. Department of Surgery, Habib Bourguiba Hospital, Sfax, Tunisia;1. Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Japan;2. Clinical Department of Pathology, Gunma University Hospital, Japan;1. Division of Anatomy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;2. MEDCENTER, Center of Excellence in Laboratory Medicine and Pathology, Bucharest, Romania;3. International Society of Regenerative Medicine and Surgery (ISRMS), Romania;4. Department of Medicine and Surgery, University of Catania, Italy;5. Division of Ophthalmology, S.C.U.O., Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;6. Clinical Hospital of Ophthalmologic Emergencies (S.C.U.O.), Bucharest, Romania;1. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China;2. School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China;3. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China;4. Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China;1. Gastroenterology Department, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia;2. General Surgery Department, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia;3. Histopathology Department, Mohamed Tahar Maamouri Hospital, Nabeul, Tunisia;4. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia;1. Bioengineering Research Center, School of Engineering, University of Kansas, Lawrence, KS, USA;2. Department of Mechanical Engineering, University of Kansas, Lawrence, KS, USA;3. Department of Civil Engineering, University of Kansas, Lawrence, KS, USA |
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| Abstract: | Gastric carcinoma (GC) is a highly aggressive malignancy with poor prognosis. It is widely accepted that malignancy results from abnormal cell growth due to dysregulation of the balance between cell proliferation and apoptosis. Our study aimed to investigate the clinicopathological and prognostic significance of p53, Ki-67, and Bcl-2 in Tunisian GC patients by immunohistochemistry. It was observed that the older patients showed p53 overexpression compared with the younger patients (p < 0.05). There was higher p53 expression in the intestinal-type compared with the diffuse-type (p < 0.05), and in well/moderate differentiated than in poor differentiated tumors. The expression of Ki-67 was positively associated with tumor size and venous invasion (p < 0.05). Bcl2 expression occurred in male patients and correlated with depth of invasion (p = 0.02). A Kaplan–Meier analysis indicated an inverse correlation between p53 and Ki-67 expression and the overall survival. Multivariate analysis revealed that the tumor site, Ki-67 and p53 expression were independent prognostic factors for gastric carcinomas (p < 0.05). Finally, combined expression of p53, Ki-67 and Bcl-2 showed that the group of patients with tumors p53+/Ki-67+/Bcl2− had aggressive behavior and poor prognosis (p log rank = 0.000). In summary, our data indicated that the expression of p53, Ki-67, and Bcl-2 may provide useful information for identifying patients with aggressive behavior and poor prognosis of GC. |
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| Keywords: | p53 Bcl-2 ki-67 Gastric carcinoma Prognosis |
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