3D打印技术在改善经鼻-蝶入路垂体腺瘤切除术患者垂体功能及并发症中的应用价值

目的 探讨3D打印技术在改善经鼻-蝶入路垂体腺瘤切除术患者垂体功能及并发症中的应用价值。 方法 选取垂体腺瘤患者96例，依据随机表分为3D组和传统组，各48例，传统组给予神经内镜下经鼻-蝶入路切除术，3D组在此基础上联合3D打印技术，比较2组围术期情况、垂体功能［泌乳素（serum prolactin,PRL）、生长激素（growth hormone,GH）、促肾上腺皮质激素（adrenocorticotropic hormone，ACTH）］、并发症。 结果 3D组肿瘤全切率明显高于传统组（P＜0.05）；术后，2组血清PRL、GH、ACTH水平比较均明显低于术前，3D组明显低于传统组，差异有统计学意义（P＜0.05），3D组术中出血量、下床时间、住院时间明显低于传统组，手术时间明显高于传统组（P＜0.05），3D组并发症发生率明显低于传统组（P＜0.05）。 结论 3D打印技术可有效提高经鼻-蝶入路垂体腺瘤切除术的切除效果，有利于改善患者垂体功能，且可减少手术创伤及并发症，值得临床推广。

The application value of 3D printing technology in improving the pituitary function and complication of patients undergoing pituitary adenoma resection via transnasal transsphenoidal approach

Objective To explore the application value of 3D printing technology in improving the pituitary function and complication of patients undergoing pituitary adenoma resection via transnasal transsphenoidal approach.Methods A total of 96 patients with pituitary adenoma were selected and divided into 3D group and traditional group according to the random number table method, with 48 patients in each group. The traditional group was treated with endoscopic transnasal transsphenoidal resection, and on this basis, 3D group was treated with 3D printing technology. The perioperative conditions, pituitary function ［serum prolactin (PRL), growth hormone (GH), adrenocorticotropic hormone (ACTH)］ and complications of the two groups were compared between two groups.Results The total tumor resection rate in 3D group was significantly higher than that in traditional group (P＜0.05). After operation, the levels of serum PRL, GH and ACTH in the two groups were significantly lower or shorter than those before operation, and significantly longer in the 3D group than in the traditional group, with a significant difference (P＜0.05). The amount of intraoperative bleeding, time of off-bed activity, and length of hospital stay in the 3D group were significantly lower or shorter than those in the traditional group, while the duration of operation was significantly longer than that in the traditional group (P＜0.05). The incidence of complications in the 3D group was significantly lower than that in the traditional group (P＜0.05).Conclusion The 3D printing technology can effectively improve the removal effect of pituitary adenoma resection via transnasal transsphenoidal approach, which is helpful to improve the pituitary function of patients, and can reduce the surgical trauma and complications. Therefore, it′s worthy of clinical promotion.