OSAHS患者血清琥珀酸表达水平及其对心血管疾病发病风险的影响

目的 探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome, OSAHS)患者血清琥珀酸水平及其对心血管疾病发病风险的影响。方法 采用连续入组的方式，选取OSAHS患者85例(轻中度组38例，重度组47例),选择与其年龄、性别、吸烟饮酒等基线特征匹配的健康对照组25例。比较OSAHS患者及健康对照组人群血清琥珀酸表达水平，同时比较OSAHS患者弗雷明翰心血管风险评分(framingham risk score, FRS);通过单因素回归分析，明确各指标对FRS的影响；进一步使用多重线性逐步回归明确琥珀酸对FRS的独立影响。结果 OSAHS患者的血清琥珀酸水平显著高于健康对照组，且随疾病程度的升高而升高；单因素回归分析显示琥珀酸、呼吸暂停低通气指数与FRS呈显著正相关，最低血氧饱和度和平均血氧饱和度与FRS呈显著负相关(P<0.05)。多重线性回归分析结果显示，OSAHS患者血清琥珀酸水平是FRS的独立影响因素。结论 血清琥珀酸水平与心血管疾病发病风险密切相关。

Expression levels of serum succinate and its impact on risk of cardiovascular disease in OSAHS patients

Objective To investigate serum succinate levels and its effect on the risk of cardiovascular disease in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Eighty-five patients(including 38 cases in the mild to moderate group and 47 cases in the severe group) with OSAHS were enrolled consecutively, and 25 healthy controls matched for age, gender, smoking and drinking at baseline were selected. Expression levels of serum succinate were compared between patients with OSAHS and healthy controls, and framingham risk score(FRS)was compared among patients with OSAHS. Univariate regression analysis was applied to clarify the effects of each indicator on FRS, and multiple linear stepwise regression was used to clarify the independent effect of succinate on FRS.Results Serum succinate levels were significantly higher in patients with OSAHS than in healthy controls, which increased with the severity of disease. Univariate regression analysis revealed that succinate and apnea-hypopnea index were significantly and positively correlated with FRS, while the lowest oxygen saturation and mean oxygen saturation were significantly and negatively correlated with FRS(P＜0.05). The results of multiple linear regression analysis showed that the serum succinate level was an independent influencing factor of FRS in patients with OSAHS.Conclusion Serum succinate levels are strongly associated with the risk of cardiovascular disease.